海洛因依赖者血清中IL-9、IL-17水平的研究

A Study on the level of IL-9,IL-17 in Sera from Heroin Addicts

目的：通过检测IL-9、IL-17在海洛因依赖者血清中水平的变化,为进一步认识海洛因对机体免疫功能的影响提供依据。方法：93例海洛因依赖者按吸食海洛因时间长短分为三组（2年以内、510年、10年以上）,31例正常人血清作为对照组,用双抗体夹心酶联免疫吸附试验（ELISA）检测各组血清IL-9、IL-17水平。结果：2年以内组和510年组海洛因依赖者血清IL-9较正常对照升高（P〈0.05）、各组IL-17水平较正常对照组降低（P〈0.05）;从2年以内组到510年组到10年以上组,IL-9水平先升高后降低[（334.92±144.41）pg/ml、（353.47±176.93）pg/ml、（287.38±129.94 pg/ml）],IL-17水平先降低后相对升高[（53.38±26.08）pg/ml、（45.87±16.81）pg/ml、（68.18±39.26）pg/ml）]。结论：IL-9、IL-17在海洛因依赖者血清中水平改变明显,吸食海洛因可刺激IL-9水平升高而抑制机体IL-17的水平表达。

Objective：By detecting IL-9,IL-17 in serum levels of heroin addicts change for a further exploration of heroin＇s effects on immune function to provide evidence.Methods：93 cases of heroin addicts were equally divided into 3 groups as those who employed to detect their sera levels IL-9,IL-17,31 cases of normal human sera were used as controls.Results：The groups of heroin addicts that had taken for less than 2 years and that had taken for 5 to 10 years had higher levels of IL-9（P〈0.05） but lower levels of IL-17（P〈0.05）,both compared to the controls.The levels of IL-9 rose at first but then went down over the range of all groups in the order of drug-taking durations（334.92±144.41 pg/ml,353.47±176.93 pg/ml,287.38±129.94 pg/ml）;while the levels of IL-17 had the opposite story,falling down firstly but ascending afterwards（53.38±26.08 pg/ml,45.87±16.81 pg/ml,68.18±39.26 pg/ml）.Conclusion：The levels of IL-9,IL-17 in the sera from the heroin addicts changed significantly.Heroin abuses were proved to stimulate the expression of IL-9 but inhibit that of IL-17 in vivo.