小剂量干扰素联合阿糖腺苷对慢性乙型肝炎病毒感染的治疗作用

Therapic effective of small doese human leucocyte interferon and arabinoside on chronic hepatitis B virus infection

报告用小剂量精制人白细胞干扰素(IFN_2)与阿糖腺苷(Ara—A)对HBsAg、HBeAg、HBV—DNA阳性慢性活动性肝炎的治疗作用。治疗组16例,治疗后观察9个月,三项乙肝标志均有阴转例,且显著高于自然阴转率。参照Merigan(1981)抗病毒药物治疗慢性肝炎效果判断标准,本组达Ⅰ型反应2例(12％):男女各1例;Ⅱ型反应14例(88％),男12例,女2例。未出现不良反应。作者讨论了抗病毒治疗过程中的有关问题。

Summary Sixteen patients with HB_sAG-, HB_eAg-and HBV-DNA positive chroic active hepatitis were given small doess of human leucocyte interferon and arabinoside. In fourty-five days, each patient was given human leucocyte interferon 115.5×10~4μ and arabinoside 4000mg. Serum HBsAg and HBV-DNA were examined before, during and after the treatment until nine months post-treatmant. The results shown three HBV replicative markers had been depended sera negative after treatment. the results indicate that small doses human leucocyte interferon and arabinoside treatment reduces serum hepatitis B virus levels by inhibiting viral replication. The group no occur side effect.