结合珠蛋白基因多态性与糖尿病视网膜病变(一)

Association of haptoglobin gene polymorphism with diabetic retinopathy in type 2 diabetes mellitus (A)

目的探讨结合珠蛋白(Hp)基因多态性与2型糖尿病(T2DM)患者糖尿病视网膜病变(DR)发病的关系。方法将317例T2DM患者分为糖尿病无视网膜病变(NDR)组和DR组,并选取100名正常人作为对照(NC)组。采用PCR技术扩增Hp1和Hp2特异的目的片段,分析Hp基因型及糖尿病(DM)病程、尿白蛋白(UAlb)等生化指标与DR的关系。结果 NDR组、DR组和NC组间Hp等位基因和基因型频率比较,均无统计学差异(P>0.05)。经Logistic回归分析显示,DM病程和24h UAlb是DR的独立危险因素,Hp可能与DR无相关性。结论 Hp基因多态性可能与DR无相关性,而DM病程和24hUAlb是DR的独立危险因素。

Objective To investigate the association between haptoglobin（Hp） gene polymorphism and the occurrence of diabetic retinopathy in patients with-type 2 diabetes mellitus. Methods The 317 type 2 diabetic patients were categorized into two groups： no diabetic retinopathy （NDR） group, diabetic retinopathy （DR） group. In addition, 100 nondiabetic individuals served as control group. The Hp genotypes were determined by PCR-RFLP, Hp genotype frequencies distribution and clinical features were compared among groups. Results There was no significant difference in Hp allele and genotype frequencies distribution among groups. There was no relationship between Hp genotypes and DR （P〉0. 05）. Additionally, logistic regression analysis showed that diabetic duration and 24 hours urinary albumin were independent risk factors for diabetic retinopathy and that the Hp genotype did not have any association with diabetic retinopathy. Conclusion The Hp polymorphism is not associated with DR. But diabetic duration and 24 hours urinary albumin are independent risk factors for diabetic retinopathy.