非折叠蛋白反应信号通路与糖尿病

蛋白质正确折叠需要一套复杂的内质网蛋白复合体的调节机制。在缺氧、氧化应激、异常糖基化反应以及钙离子稳态失衡等情况下，非折叠蛋白质增多。当超出内质网的处理能力时，可导致内质网应激（ERS）。细胞自身通过改变其转录和翻译过程，减少蛋白质的合成，降低进入内质网内蛋白质的数量，同时上调内质网中分子伴侣和蛋白折叠的表达，增强内质网的蛋白折叠功能；

Objective To explore the relationship of plasma visfatin level with insulin resistance and blood glucose after insulin glargine therapy in type 2 diabetic patients. Methods A total of 32 diabetic patients and 26 healthy controls matched for age and gender were enrolled.Fasting plasma glucose(FPG), postprandial blood sugar (2hPG),triglyceride(TG),glycosylated hemoglobin (HbA1c), fasting insulin(Fins), insulin resistance index (HOMA-IR),insulin secretion index (HOMA-β)and plasma visfatin were measured and analyzed. Results There were significant differences in TG, FPG, 2hPG, HbAlc, HOMA-IR and HOMA -β before therapy versus after therapy(P<0.05), and plasma visfatin level was reduced after therapy(P<0.01). The visfatin level was lower in type 2 diabetic patients than in controls (P< 0.01). Plasma visfatin level was positively correlated with HbAlc,FIns and HOMA-IR (r=0.259,P<0.05;r=0.586,P<0.01; r=0.385,P<0.01). Multiple regression analysis showed that HOMA-IR was an independent related factor for plasma visfatin level. Conclusions Plasma visfatin level of type 2 diabetic patients is related to insulin resistance and average blood glucose,which may contribute to insulin resistance and type 2 diabetes mellitus.