新生儿缺氧缺血性脑病预后评估进展

Research Progress in the Assessment of Prognosis of Hypoxic Ischemic Encephalopathy

新生儿缺氧缺血性脑病(HIE)的预后,与窒息程度、脑损害程度、开始治疗时间以及干预手段有关。目前对HIE的预后主要从临床症状、脑的形态学改变、脑功能变化、实验室检查等多角度综合判断。NBNA评分、头颅影像学检查、脑电图、脑干诱发电位、肌酸激酶、8异-前列腺素F2α、血清神经元特异性烯醇化酶等检查可以从不同角度反映脑损害程度,对判断预后有重要作用。

The prognosis of hypoxic ischemic encephalopathy（HIE） is associated with the severities of asphyxia,cerebral damages,timing of treatment and interventional regimens.At present,the comprehensive evaluation of HIE prognosis is mainly dependent on clinical symptoms,brain morphological variation,brain function alteration,and laboratory examination.NABA scoring,brain imaging,electroencephalography,brainstem induced potential,creatine kinase,8-iso-prostaglandin F2α,and serum neuron specific enolase are useful for the assessment of brain damage and prognosis from various perspectives.