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β受体阻断剂在慢性心衰中作用的基础机制 被引量:3

The Basic Mechanism of Beta-blocker in Chronic Heart Failure
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摘要 心力衰竭是很多心血管疾病的最终阶段,也是常见的致死原因之一。心力衰竭时起代偿作用的交感神经系统的持续兴奋是导致心力衰竭恶化的一个重要原因。近年来,众多临床试验证实β受体阻断剂类药物对心力衰竭有良好的治疗作用,β受体阻断剂能通过慢性抑制交感神经的兴奋,改善心力衰竭患者心功能,从而减少患者病死率,增加生存率。 Heart failure is the final phase for many cardiovascular diseases,one of the common fatal causes as well.One important reason of heart failure deterioration is the sustained excitement of sympathetic nervous system which is a compensatory mechanism in heart failure.In recent years,evidence has been accumulated on the beneficial actions of beta-blockers in patients with heart failure.The effect of beta-blocker in chronic inhibition of sympathetic nervous system can improve cardiac function of heart failure patients,reduce mortality and increase survival rates.
出处 《医学综述》 2011年第10期1516-1518,共3页 Medical Recapitulate
关键词 心力衰竭 Β受体阻断剂 基础机制 Heart failure Beta-blocker Basic mechanism
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  • 1Jones DL,Adams R,Carnethon M,et al.Heart disease and stroke statistics--2009 update:a report from the American heart association statistics committee and stroke statistics subcommittee[J].Circulation,2009,119(3):480-486.
  • 2Metra M,Nodari S,Bordonali T,et al.Bisoprolol in the treatment of chronic heart failure:from pathophysiology to clinical pharmacology and trial results[J].Ther Clin Risk Manag,2007,3(4):569-578.
  • 3Valgimigli M,Ceconi C,Malagutti P,et al.Tumor necrosis factor-{alpha} receptor 1 is a major predictor of mortality and new-onset heart failure in patients with acute myocardial infarction:The cytokine-activation and long-term prognosis in myocardial infarction (c-alpha) study[J].Circulation,2005,111(7):863-870.
  • 4Bristow MR.β-adrenergic receptor blockade in chronic heart failure[J].Circulation,2000,101(5):558-569.
  • 5Bristow MR,Feldman AM,Adams KF,et al.Selective versus nonselective β-blockade for heart failure therapy:are there lessons to be learned from the COMET trial?[J].J Cardiac Failure,2003,9(6):444-453.
  • 6Matos LD,Gardenghi G,Rondon MU,et al.Impact of 6 months of therapy with carvedilol on muscle sympathetic nerve activity in heart failure patients[J].J Card Fail,2004,10(6):496-502.
  • 7Triposkiadis F,Karayannis G,Giamouzis G,et al.The sympathetic nervous system in heart failure:physiology,pathophysiology,and clinical implications[J].J Am Coll Cardiol,2009,54(19):1747-1762.
  • 8Lowes BD,Gilbert EM,Abraham WT,et al.Myocardial gene expression in dilated cardiomyopathy treated with beta-blocking agents[J].New Engl J Med,2002,346(18):1357-1365.
  • 9Lechat R,Brunhuber P,Hofmann KW,et al.The cardiac insufficiency bisoprolol study II (CIBIS-II):a randomised trial[J].Lancet,1999,353(9146):9-13.
  • 10Rozec B,Erfanian M,Laurent K,et al.Nebivolol,a vasodilating selective {beta}1-blocker,is a {beta}3-adrenoceptor agonist in the nonfailing transplanted human heart[J].J Am Coll Cardiol,2009,53(17):1532-1538.

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