阿昔洛韦缓释片在不同介质中的释放研究

Drug Release of Aciclovir Sustained-release Tablets in Different Media

目的:研究阿昔洛韦缓释片在不同介质中的体外释药特性。方法:以转篮法进行溶出度研究;采用紫外分光光度法在254nm波长下测定阿昔洛韦缓释片在4种释放介质即0.1mol·L-1盐酸液、pH6.8磷酸盐缓冲液、蒸馏水和由0.1mol·L-1盐酸液(前2h)与pH6.8磷酸盐缓冲液(2h后)组成的替换介质中的12h内的释放度,并进行释放行为模型的拟合。结果:阿昔洛韦缓释片在盐酸液中的释放速度最快,但12h时4种介质中阿昔洛韦皆释放完全;阿昔洛韦在4种介质中体外释药拟合模型更接近Higu-chi方程和Peppas方程。结论:阿昔洛韦缓释片在不同介质中均具有缓释性,释放机制主要为扩散释药。

OBJECTIVE：To study the release characteristics of Aciclovir sustained-release tablets in vitro.METHODS：Drug release rate study was conducted using basket method.The drug release rates of Aciclovir sustained-release tablets in 4 kinds of media at wavelength of 254 nm for 12 h were determined by UV spectrophotometry,i.e.0.1 mol·L-1 hydrochloric acid,pH6.8 phosphate buffer solution,distilled water and pH 6.8 phosphate buffer solution instead of 0.1 mol·L-1 hydrochloric acid 2 h later.RESULTS：The drug release of Aciclovir sustained-release tablets was the fastest in hydrochloric acid.12 h later,Aciclovir sustained-release tablets was released completely in 4 kinds of media.In vitro drug release of Aciclovir sustained-release tablets was consistent with Higuchi equation and Peppas equation in 4 kinds of media.CONCLUSION：The drug release profile of Aciclovir sustained-release tablets shows an obvious property of sustained-release,which meets diffusion drug release.