6-硝基-L-多巴的合成

Synthesis of 6-Nitro-L-DOPA

以3,4-二羟基-L-苯丙氨酸为原料,通过羟基保护、硝化、脱保护、Boc保护等反应合成了药物中间体——6-硝基-L-多巴,总收率58%,其结构经1HNMR和HPLC-MS确证。

A key drug intermediate,6-nitro-L-DOPA,was obtained by protected hydroxyl,nitrifying,removing the protecting group and conducting the Boc protection from 3,4-dihydroxyl-L-phenylalanine in total yield of 58%.The structure was confirmed by 1H NMR and HPLC-MS.