利用Mitsunobu反应合成川芎嗪衍生物

Synthesis of Tetramethylpyrazine Derivatives by Mitsunobu Reaction

以川芎嗪为起始原料,利用Mitsunobu反应合成了三个3,5,6-三甲基吡嗪-2-基-甲氧基苯甲醛衍生物,收率87%～92%,其结构经1HNMR,13C NMR和ESI-MS表征。

Three tetramethylpyrazine derivatives in yields of 87%～92% were synthesized by Mitsunobu reaction from tetramethylpyrazine.The structures were characterized by 1H NMR,13C NMR and ESI-MS.