摘要
酵米面与变质银耳中毒是由椰毒假单胞菌引起的。此菌产生两种毒素:毒黄素和米酵菌酸。本研究显示以含维生素E的饲料饲喂小白鼠7天,可保护动物使之耐受毒黄素2μg/g体重的腹腔注射,使之不发生中毒,而喂正常饲料的小鼠在此毒素剂量攻击下全部死亡。超氧化物岐化酶与触酶只有当静脉注射时才有治疗毒黄素中毒的效果,还原性谷胱甘肽与维生素C则无效。试验了二巯基丙醇与半胱氨酸对米酵菌酸中毒的疗效,前者明显有效,可使腹腔注射米酵菌酸(1.2μg/g体重)的小鼠绝大部分存活,而未治疗的或用半胱氨酸治疗的小鼠则绝大部分死亡。由此提示,此菌中毒可用二巯基丙醇和维生素E来治疗。
Fermented corn meal and deteriorated tremella(white fungus)poisoning is caused by Pseudomonas cocovenenans. The bacterium produces two toxins: toxoflavin and bongkrekic acid. In this study, it was shown that administrating vitamin E orally 7 d in a row before abdominal injection of toxoflavin to mice (2ug/g body wright), the mice were protected from toxieation, whereas the mice in the control group were all dead. SOD and catalase were effective only when giving by i. v. immediately following the injection of toxoflavin. GSH and VC have no effect in curing the toxication. Bongkrekic acid poisoning was treated by dimercaprol (BAL)and L-cysteine respectively and it was shown that the former was more effective in curing the poisoning (the dose of bongkrekic acid is 1.8μg/g); ten elevenths animal were saved in contrast with the control group, in which only one eighth animal were survived.
出处
《潍坊医学院学报》
1990年第3期1-3,15,共4页
Acta Academiae Medicinae Weifang
关键词
毒黄素
米酵菌
酸中毒
解毒
酵米面
Pseudomonas cocovenenans
toxoflavin
bongkrokic acid
vitamin E
dimercaprol
