摘要
目的重点对左乙拉西坦的合成工艺进行优化。方法以L-蛋氨酸为原料经脱硫甲基化、酯化、氨解、酰胺化及分子内缩合成环反应最终得左乙拉西坦。结果以L-蛋氨酸计左乙拉西坦总收率约48.0%。结论改进的工艺明显提高了反应收率,工艺条件温和,合成步骤简洁,适合工业化生产。
Aim To explore the optimizationed synthetic route for Levetiracetam.Methods Levetiracetam was prepared from L-methionine viareduction-dethiomethylation,esterification,ammonolysis,amidation and intramolecular cyclocondensaion reaction.Results The overall yield was 48.0% calculated from L-methionine.Conclusion The reaction yield was hihger,no strict reaction conditions,simplified route and more sutable to be industrilialized.
出处
《安徽医药》
CAS
2011年第6期681-683,共3页
Anhui Medical and Pharmaceutical Journal
关键词
左乙拉西坦
合成
优化
levetiracetam
synthesis
optimization
