盐酸安妥沙星注射液与几种常用输液配伍的稳定性

Compatibility stability of antofloxacin hydrochloride injection with four kinds of intravenous transfusion

目的考察盐酸安妥沙星注射液与4种常用输液(5%葡萄糖注射液、10%葡萄糖注射液、0.9%氯化钠注射液、葡萄糖氯化钠注射液)配伍后的稳定性。方法采用高效液相色谱法考察盐酸安妥沙星注射液与上述4种输液配伍后6 h内含量的变化情况,同时观察外观并测定pH值。结果室温放置6 h内,各配伍溶液外观性状,pH值及含量均无明显变化。结论盐酸安妥沙星注射液与4种常用输液配伍后室温放置6 h内稳定。

Aim To study the stability of antofloxacin hydrochloride injection with four kinds of intravenous transfusion（5% glucose injection,10% glucose injection,0.9% sodium chloride injection,and glucose and sodium chloride injection）.Methods The changes in appearance and pH values were observed,and the content was determined by HPLC.Results Within 0~6 hours at room temperature,the appearance,pH values and its content had no obvious changes.Conclusion Antofloxacin hydrochloride injection with four kinds of intravenous transfusion is stable essentially for 6 hours.