摘要
利用从椰毒假单胞菌(Pseudomona cocovenenans)中所分离提取的毒黄素(toxoflavin)对黄嘌呤氧化酶(EC.1.2.3.2)作用的动力学试验表明,毒黄素是此酶的非必需激活剂,而且对以次黄嘌呤为底物的反应的激活作用明显高于以黄嘌呤为底物的反应。此激活作用属于部分混合型。这一结果为探寻毒黄素对人的致毒机理提供了一条重要线索。
The kinetic studies of effect of toxoflavin on the action of xanthine oxidase (EC 1, 2, 3, 2) which was extracted from Pseudomons cocovenenans showed that toxoflavin was nonessential activator for the enzyme, and the activation in condition of hypoxanthine as substrate was more marked than xanthine. The activation obeyed the partial actvation type. These results provide us a lead for searching toxic mechanism of toxoflavin for human.
出处
《潍坊医学院学报》
1990年第3期20-23,共4页
Acta Academiae Medicinae Weifang
关键词
毒黄毒
黄嘌呤氧化酶
toxoflavin
xanthine oxidase
partial activation
