摘要
目的:通过对注射用盐酸吉西他滨的安全性试验研究,评价其用药的安全性。方法:分别进行豚鼠全身过敏性试验,家兔血管刺激性试验及溶血性试验,观察注射用盐酸吉西他滨是否可引起过敏和对血管的刺激性,是否具有溶血作用。结果:注射用盐酸吉西他滨给药后未出现过敏反应,静脉注射未见明显刺激性,亦未见溶血及凝集反应。结论:注射用盐酸吉西他滨用药安全可靠。
Objective: To evaluate the safety of gemcitabine hydrochloride injection.Methods: Sensitivity test,blood vessel stimulation test and hemolysis test were conducted on guinea pig and rabbits to observe whether gemcitabine hydrochloride could induce hypersensitive response,irritative response,hemolutic reaction and agglutination or not.Results: Neither hypersensitive reaction in guinea pig nor hemolytic reaction or agglutination in rabbits was observed no matter gemcitabine hydrochloride was administrated by intramuscular injection.Conclusions: The results indicate that gemcitabine hydrochloride injection is safe.
出处
《海南医学院学报》
CAS
2011年第5期589-591,共3页
Journal of Hainan Medical University
基金
海南医学院科研基金资助学报项目(0020110139)
关键词
注射用盐酸吉西他滨
刺激性
过敏性
溶血性
Gemcitabine hydrochloride for Injection
Stimulation
Allergic
Hemolysis