骨郎格汉斯细胞组织细胞增生症10例临床及病理学特点

Cytopathological characteristic of langerhans cell histocytosis in bone

目的:通过细针吸取细胞学(FNAC)检查探讨骨郎格汉斯细胞组织细胞增生症(LCH)的细胞病理学特点,并结合文献对本疾病进行再认识。方法:使用一次性注射器,在骨肿瘤病灶内作穿刺检查,抽吸物涂片,瑞氏染色,3例作免疫细胞化学染色,光镜观察。结果:细胞学诊断骨LCH10例,其中9例经术后病理组织学证实,诊断准确率达90%。结论:本病具有特征性细胞学形态改变,临床特点鲜明,FNAC检查能在术前对本病作出快速、准确诊断,是本病重要的术前检查方法之一。

Objective： To explore the cytopathological characteristic of langerhans cell histocytosis（LCH） in bone by fine needle aspiration cytology（FNAC）.Methods： Puncture was performed in the focus of bone tumor by disposable syringe.The smear of aspirate was made and stained by Wrights′ staining.Three cases were stained by immunocytochemical staining.All were observed under light microscope.Results： Ten LCH cases were diagnosed by FNAC,in which 9 were confirmed by immunocytochemical assay.The accuracy of diagnosis was 90%.Conclusions： Characteristic changes in cytological morphology occur in LCH patients.FNAC is rapid and accurate.It is an mportant examination method.