摘要
目的:探讨血清中巨噬细胞移动抑制因子(MIF),胰岛素样生长因子-2(IGF-2),瘦素(leptin)和泌乳素(PRL)水平与卵巢癌的关系。方法:应用液相芯片技术检测20例卵巢癌术患者,35例卵巢良性肿瘤患者和30例卵巢子宫内膜异位囊肿患者血清中IGF-2l、eptin、MIF和PRL的水平,并进行比较。结果:卵巢癌手术前、后患者IGF-2、Leptin以及MIF水平差异有统计学意义(P<0.05);卵巢癌手术组与良性卵巢病变组间IGF-2和MIF水平的差异有统计学意义(P<0.01,P<0.05)。结论:IGF-2l、ep-tin和MIF与卵巢癌有一定的关系,其对卵巢癌的诊断价值值得进一步研究。
Objective： To discuss the relation between the serum levels of insulin-like growth factor-2（IGF-2）,Leptin,prolactin（PRL） and macrophage migration inhibition factor（MIF） and diagnosis of ovarian cancer.Methods：By multiplexed Luminex assay,serum levels of IGF-2,Leptin,PRL and MIF were measured and compared in 20 patients with ovarian cancer,35 with benign ovarian tumor and 30 with ovarian endometriosis patients.Results：There were significant differences in serum levels of IGF-2,Leptin and MIF in patients with ovarian cancer before and after surgery（P0.05）.Serum levels of IGF-2 and MIF in patients with ovarian cancer were significantly different from those of patients with benign ovarian tumor（P0.01 and P0.05,respectively）.Conclusions：Changes of serum levels of IGF-2,Leptin and MIF were associated with ovarian cancer.The further study on their diagnostic value is needed.
出处
《海南医学院学报》
CAS
2011年第5期604-606,609,共4页
Journal of Hainan Medical University
基金
海南医学院科研基金资助学报项目(0020110143)
