精子质量与胚胎质量

Sperm quality and embryo quality

衡量男性的生殖能力一般采用WHO的精液分析标准,包括精子的活力、密度、畸形率等,然后结合女方的一些相关检查,为夫妇选择适应的妊娠方式。对于婚后1年规律性生活仍未怀孕者,则认为是不孕,应选择合适的助孕治疗。随着卵胞浆内单精子注射(ICSI)的发展,男性不育得到了有效的治疗,但ICSI却使精子的自然选择作用消失,操作过程中有可能选择了质量差的精子进行受精,其胚胎的发育和质量。

As to male factor infertility with very poor semen parameters, the fertilization rate and pregnancy rate were both very poor before the use of Intraeytoplasmic sperm injection （ICSI）. ICSI has dramatically increased the fertilization rate in this kind of patients, while embryo development, implantation rate and clinical pregnancy rate are not accordingly improved. It has been well documented that sperm quality affects not only fertilization but also embryo development. Sperm quality has a great impact on human embryo morphology, early cleavage and formation of blastocysts, and implantation of embryo as well. This article reviews the studies on the correlation of sperm quality with embryo quality.