摘要
目的:探讨乌司他丁(ulinastatin,UTI)对急性肺损伤/急性呼吸窘迫综合征(acute lung injury/acute respiratory distress,ALI/ARDS)的治疗效果。方法:ALI/ARDS患者40例,随机分为UTI治疗组(n=20)和对照组(n=20);对照组接受常规治疗,UTI治疗组在常规治疗基础上静脉推注乌司他丁20万u,每8h 1次,连用10天。观察两组的临床疗效、治疗前后心率、呼吸、、动脉血气以及血清肿瘤坏死因子-α(TNF-α)、IL-6水平变化。结果:治疗组有效率90.0%,明显高于对照组65.0%(X^2=3.856,P<0.05);两组治疗前后各项指标比较均有统计学差异(t=2.231、2.311、2.215、2.301、2.315、2.333、2.341、2.401、2.451、2.342、2.332、2.333,P均<0.05);两组治疗8d,Pa0_2、心率、呼吸、有显著性差异(t=2.232、2.311、2.3415,P均<0.05);两组治疗前后TNF-α、IL-6含量差异有统计学意义(t=2.378、2.431、2.331、2.322,P均<0.05),结论:乌司他丁减轻炎性反应对机体的损伤,改善ALI/ARDS的预后。
Objective To investigate the curative effect of ulinastatin on acute lung injury/acute respiratory distress syndrome(ALI/ARDS).Methods 40 patients with ALI/ARDS were randomly divided into treatment group (n=20)and control group (n= 20).The control group received only the routine therapy, and the treatment group were given ulinastatin(200 ku intravenously, once every 8 hours, and continued for 10 days) in addition to the routine treatment.The Methods:Thirty-four patients with ALI/ARDSwere randomly divided into treatment group(n=17) and control group (n=17). The control group received only the routine therapy, and the treatment group were given ulinastatin (200 ku intravenously,once every 8 hours, and continued for 10 days) in addition to the routine treatment.The index of clinical efficacy,heart rate,breathing, arterial blood gas,serum tumor necrosis factor-or (TNF-a).Interleukin -6 (IL-6) before treatment and after treatment were observed.Results The effet rate 90.0% in treatment group were significantly higher than 65.0% in control group (X2=3.856,P〈0.05);The projects Comparative before and after treatment in both groups were statistically significant (t=2.231,2.311,2.215,2.301,2.315.2.333,2.341,2.401,2.451,2.342,2.332,2.333, all P〈0.05); The index of PaO2.heart rate, breathing in two groups were significant difference(t=2.232,2.31 1,2.3415,all P〈0.05).Conclusion Ulinastatin may prevent the systemic injury by inflammatory response and improve the prognosis of ALI/ARDS.
出处
《内蒙古中医药》
2011年第10期82-83,共2页
Inner Mongolia Journal of Traditional Chinese Medicine
关键词
呼吸窘迫综合征
乌司他丁
疗效
Acute respiratory distress syndrome
Ulinastatin
curative effect