水溶性五环三萜酸衍生物的制备及研究进展

Advances in the Research on Preperation of Water-soluble Derivatives of Pentacyclic Triterpenoid Acid

综述几种常见水溶性五环三萜酸衍生物的研究进展。五环三萜酸类化合物多具有广泛的生物活性,但因水溶性差、生物利用度低使其临床应用受到限制。以五环三萜酸为先导化合物,经结构修饰合成水溶性衍生物,并从中寻找出有生物活性和临床应用价值的化合物是当前天然药物化学研究的热点之一。

Recent advances in the studies on derivatives of five kinds of water-soluble pentacyclic tri-terpenoid acids has been reviewed.Pentacyclic triterpenoid acid possesses various biological activites.However,it is limited in the clinical application due to its poor solubility and low bioavailability.Therefore,it has become an interesting subject for the researchers to use pentacyclic triterpenoid acids as lead compounds to synthesize the water-soluble derivatives and to search for the candidate compounds having bioactivities and clinical value.