义齿稳固剂的口腔黏膜刺激性及对咬合力的影响

Oral Mucous Membrane Irritation Test and Biting Force Measurement of a New Denture Adhesive

目的初步探讨自行研制的纤维素类义齿稳固剂(denture adhesive,DA)对口腔黏膜的刺激性和临床应用效果。方法健康金黄地鼠10只随机分为2组,麻醉后,其中1组动物口腔左侧黏膜放置DA浸提液,另1组置入阳性对照材料,2组动物口腔右侧黏膜均放置阴性对照材料。分别于1、4、6、8 h后肉眼观察局部黏膜改变,并做组织切片了解组织学改变。临床测定20例患者使用DA前后,新旧全口义齿最大咬合力的变化。结果实验动物均未出现局部及全身的不良刺激反应。所研制的稳固剂可提高新旧全口义齿的最大咬合力,但仅旧义齿使用前后差异有统计学意义(t=3.584,P<0.01)。结论所研制的DA义齿稳固剂未见对口腔黏膜的不良刺激反应,DA可提高旧义齿的最大咬合力,有较好的临床应用前景。

Objective To evaluate local and systemic response to the developed synthetic denture adhesive（DA）,by oral membrane irritation test.Clinical investigation was discussed in this article as well.Methods Ten hamsters were used in this research and divided into 2 groups evenly.The eluates of DA and positive control materials were fixed on the left of oral membrane of each 5 hamsters＇ pouch separately,while the negative materials were put on the right side of all the 10 tested animals.After 1 h,4 h,6 h and 8 h of local and systemic observation,the local oral membrane specimens were viewed under microscope.Twenty edentulous patients with complete dentures were selected for this research also.The maximum biting force was recorded before and after application of the adhesive to all the new and old dentures.Results The results showed that there were no local or systemic abnormal response to the test material.The clinical investigation data indicated that significantly greater biting forces were generated with old dentures than with the new dentures.Conclusion The developed DA exhibited no abnormal oral mucous membrane irritating response and the generally favorable clinical performance indicated that it might be an efficacious denture adhesive.