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抑制NF-KB治疗哮喘研究现状 被引量:2

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摘要 支气管哮喘是一种气道慢性变态反应性炎症,并伴随多种炎症细胞,炎症介质及细胞因子的参与.转录因子-kB(NF-kB)与哮喘的关系许多年来一直受到国内外大量学者的关注,很多研究已经证实NF-kB参与哮喘的发病机制,而抑制NF-kB表达活性能在一定程度上治疗哮喘.本文就近年来通过阻断NF-kB表达来治疗哮喘作一综述. Bronchus asthma is a chronic inflammatory reaction of the press, and accompanied by a variety of inflammatory cells, and inflammatory cells involved, the transcription factor - kb (nf - kb) relations with asthma many years been a great deal of scholarly attention home and abroad, many studies have proved nf - kb involved in the mechanism, and discourages nf - kb expression of activity in a.certain extent involved, this treatment is in recent years by an expression of nf - kb for asthma, make a review ;
作者 王萍 唐德义
出处 《医学信息(下旬刊)》 2011年第4期340-340,共1页 Medical information
关键词 NF-KB 哮喘[治疗 NF-kB Asthma Treatment
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参考文献11

  • 1Solt LA,May MJ.The IKB Kinase Complex:Master Regulator of NF-kB Signaling[J].Immunol Res,2008,42(1-3):3-18.
  • 2Nguyen C,Teo JL,Matsuda A,et al.Chemogenomic Identification of Ref-1/AP-1 as a Therapeutic Target for Asthma[J].Proc Natl Acad Sci U S A,2003,100(3):1169-1173.
  • 3Caramori G,Papi A.Oxidants and Asthma[J].Thorax,2004,59:170-173.
  • 4Lee KS,Kim SR,Park HS,et al.A Novel Thiol Compound,N-acetylcysteine Amide,Attenuates Allergic Airway Disease by Regulating Activation of NF-kB and Hypoxia-inducible Factor-1α[J].Exp Mol Med,2007,39(6):756-768.
  • 5王宏伟,邵玉霞,梁蕊.糖皮质激素对哮喘大鼠气道上皮细胞NF-κB、ICAM-1表达的影响[J].中国康复理论与实践,2006,12(1):41-42. 被引量:2
  • 6Lee SH,Seo MJ,Choi SM,et al.DA-9201 Shows Anti-Asthmatic Effects by Suppressing NF-kB Expression in an Ovalbumin-Induced Mouse Model of Asthma[J].Arch Pharm Res,2005,28(12):1350-1357.
  • 7Elliott PJ,Zollner TM,Boehncke WH.Proteasome Inhibition:a New Anti-Inflammatory Strategy[J].J Mol Med,2003,81:235-245.
  • 8Birrell MA,Hardaker E,Wong S,et al.IKB Kinase-2 Inhibitor Blocks Inflammation in Human Airway Smooth Muscle and a Rat Model of Asthma[J].Am J Respir Crit Care Med,2005,172:962-971.
  • 9Ziegelbauer K,Gantner F,Lukacs NW,et al.A Selective Novel Low Molecular Weight Inhibitor of IKB Kinase-β(IKK-β) Prevents Pulmonary Inflammation and Shows Broad Anti-Inflammatory Activity[J].Br J Pharmacol,2005,145:178-192.
  • 10Tak PP,Firestein GS.NF-kB:a Key Role in Inflammatory Diseases[J].J Clin Invest,2001,107(1):7-11.

二级参考文献5

  • 1张志平.压缩雾化吸入辅助治疗小儿哮喘时的行为干预[J].中国康复理论与实践,2005,11(4):308-308. 被引量:1
  • 2Blackwell TS,Christman JM.The role of factor-kappa B in cytokine gene regulation[J].Am J Pespir Cell Mol Biol,1997,17:3-9.
  • 3Vignola AM,Mirabella F,Costanzo G,et al.Airway wall in asthma[J].Chest,2003,123(3 suppl):417s-22s.
  • 4Holgate ST.Inflammation and structural changes in the airway of patients with asthma[J].Respirt Med,2000,94:53-56.
  • 5Wilson JW,Li X.The measurement of reticular basement membrane and submucosal collagen in the asthmatic airway[J].Clin Exp Allergy,1997,27(4):363-371.

共引文献1

同被引文献29

  • 1孙余才,胡国华,朱江.喉癌组织中核转录因子NF-kB的定量检测[J].山东大学耳鼻喉眼学报,2007,21(2):141-143. 被引量:3
  • 2李占君,侯兴宁.血细胞分析仪对白细胞分类结果的分析[J].宁夏医学杂志,2007,29(10):943-944. 被引量:5
  • 3Wenzel SE. Asthma phenotypes:the evolution from clinical to molecular approaches[J].Nature Medicine,2012.716-725.
  • 4Chung KF. The role of airway smooth muscle in the pathogenesis of airway wall remodeling in chronic obstructive pulmonary disease[J].PROCEEDINGS OF THE AMERICAN THORACIC SOCIETY(PATS),2005.347-354.
  • 5Lukacs NW,Strieter RM,Chensue SW. TNF-alpha mediates recruitment of neutrophils and eosinophils during airway inflammation[J].Journal of Immunology,1995.5411-5417.
  • 6Tliba O,Amrani Y,Panettieri RA Jr. Is airway smooth muscle the "missing link" modulating airway inflammation in asthma[J].Chest,2008,(01):236-242.
  • 7Ammit AJ,Lazaar AL,Irani C. Tumor necrosis factor-alpha-induced secretion of RANTES and interleukin-6 from human airway smooth muscle cells:modulation by glucocorticoids and beta-agonists[J].American Journal of Respiratory Cell and Molecular Biology,2002.465-474.
  • 8Pang L,Knox AJ. Regulation of TNF-alpha-induced eotaxin release from cultured human airway smooth muscle cells by beta2-agonists and corticosteroids[J].Federation of America Societies for Experimental Biology Journal,2001.261-269.
  • 9Young CN,Koepke JI,Terlecky LJ. Reactive Oxygen species in tumor necrosis factor-alpha-activated primary human keratinocytes:implications for psoriasis and inflammatory skin disease[J].Journal of Investigative Dermatology,2008.2606-2614.
  • 10Barnes PJ,Adcock IM,Ito K. Histone acetylation and deacetylation:importance in inflammatory lung diseases[J].European Respiratory Journal,2005.552-563.

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