Caveolin-1在浸润性乳腺癌间质中的表达及临床病理意义

Significance and expression of stromal Caveolin-1 in invasive breast cancer

目的:探讨窖蛋白-1(Caveolin-1)在乳腺癌间质中的表达及其与乳腺癌发生、发展及转移的关系。方法:运用免疫组织化学SP法研究Caveolin-1在正常乳腺癌间质和正常乳腺间质中的表达。结果:80例乳腺癌组织中间质Caveolin-1的表达阳性率分别为55%,而在36例正常乳腺组织中间质Caveolin-1的表达阳性率为75%,两者比较有显著差异(P=0.042);间质Caveolin-1的表达阳性率在乳腺癌高、中分化组明显高于低分化组,转移阳性组明显高于转移阴性组,其差异均有统计学意义(P=0.025);复发组间质Caveolin-1的表达阳性率也明显低于未复发组,其差异有统计学意义(P=0.012)。K-M生存曲线显示间质Caveolin-1的表达阴性患者的无瘤生存率也明显低于间质Caveolin-1的表达阳性患者(P=0.008)。多因素COX逐步回归分析结果显示间质Caveolin-1是无瘤生存率(P=0.031)的独立因素。结论:间质Cave-olin-1可能在乳腺癌的发生、发展及转移过程中起着关键性作用。

Objective： To detect the stromal expression of Caveolin-1 in breast cancer,and evaluate the association between clinicopathological parameters and breast carcinogenesis.Methods：By immunohistochemical SP method,the expression of stromal Caveolin-1 in the tissues of 80 cases of breast cancer patients and 36 cases of normal ones were evaluated,and its relationship with clinical and pathological features was analyzed.Results：The positive rate of stromal Caveolin-1 in normal breast tissue was 55%,which was significantly higher than 35%of the breast cancer（P=0.042）.The positive rate of stromal Caveolin-1 expression in the high differentiated and moderately differentiated groups was significantly higher than the poorly differentiated group,and metastasis negative group was significantly higher than the positive ones（P=0.025）;the positive rate of stromal Caveolin-1 expression was significantly higher in the recurrence group than the group without recurrence（P=0.012）.K-M survival curve showed the survival rate was significantly lower in the negative expression of the stromal Caveolin-1 patients compared to the positive ones（P= 0.008）.Multivariate COX proportional hazards model analysis also showed that the expression rate of the stromal Caveolin-1 was an independent predictor of disease-free survival（P= 0.031）.Conclusion：Loss of stromal Caveolin-1 may play an important role in the development and metastasis of breast cancer.