CD34在鼻息肉组织中的表达及意义

Expression and roles of CD34 in nasal polyps

目的检测CD34在鼻息肉组织中的表达,探讨CD34+细胞在鼻息肉上皮修复和炎症反应中的作用。方法采用免疫组织化学方法检测10例鼻息肉组织和10例对照中鼻甲黏膜组织中的表达。结果 4例鼻息肉上皮基底细胞可见CD34表达,在中鼻甲黏膜上皮中未见CD34表达。在鼻息肉和对照中鼻甲黏膜上皮下固有层中可见到CD34+炎症细胞和血管内皮细胞。鼻息肉上皮CD34阳性表达率以及固有层中的CD34+炎症细胞数量明显高于对照中鼻甲黏膜。结论鼻息肉组织中CD34+基底细胞可能参与鼻息肉上皮细胞损伤修复,同时在鼻息肉组织固有层中存在较为活跃的原位造血过程。

OBJECTIVE To evaluate the expression and the role of CD34 in nasal polyps.METHODS Immunohistochemistry was used to detect the CD34＋ cells in 10 cases of nasal polyps and 10 control middle turbinate mucosa.RESULTS CD34 was expressed in the basal cells of four nasal polyps,and in the inflammatory cells and endothelial cells in lamina propria of nasal polyps and control mucosa.The positive rate of CD34 and the number of inflammatory cells in nasal polyps was significantly higher than those in control mucosa.CONCLUSION CD34＋ basal cells may contribute to the repair of epithelium of nasal polyps.In situ hemapoiesis may play important role in nasal polyps.