颅面骨纤维骨病变

Fibro-osseous Lesions of Craniofacial Bones

纤维骨病变这一概念已经提出了几十年,这类疾病一直受到临床医师以及病理学家的关注。在过去的这段时间,有一些新的病变被提出,并对这类疾病的诊断和治疗也提出了新的观点和争议。作者针对颅颌面纤维骨病变的临床病理特征和病因机制进行分类,并分别阐述。

Fibrous-ossesous lesions of the craniomaxillofacial bones represent a diverse group of pathological conditions that includer developmental lesions,reactions or dysplastic diseases,and neoplasms.Several new entities have been delineated and new concepts and controversies regarding their diagnosis and management of these lesions have arisen.Owing to substantial overlap of these histopathologic findings,subclassification of fibrous-osseous lesions may be problematic.Moreover,this is not merely an academic exercise,because the therapeutic management of fibrous-osseous lesions varies depending on the actual disease process.The objective of this article is to review the most clinicopathologic,radiographic,and molecular studies of fibrous-osseous lesions to aid the clinical pathologist in the recognition and diagnosis of this diverse group of craniomaxillofacial lesions.