阻塞性睡眠呼吸暂停低通气综合征与肾功能损害的相关性分析

Correlation between obstructive sleep apnea hypopnea syndrome and kidney damage

目的探讨中、重度阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者血清尿酸、肌酐、尿素氮水平的变化及临床意义,并分析其相关性。方法选择中、重度OSAHS患者100例及对照组44例作为研究对象,观察各组血清尿酸、肌酐、尿素氮水平的变化,比较OSAHS不同程度间各观察指标的差异;对OSAHS组血清尿酸、肌酐水平与睡眠呼吸暂停低通气指数(AHI)、最低血氧饱和度(LSaO2)进行相关性分析。结果中、重度OSAHS组血清尿酸、肌酐水平与对照组比较差异均有统计学意义(P<0.05)。OSAHS组血清尿酸水平与AHI呈正相关(P<0.05),与LSaO2(P<0.05)呈负相关。结论中、重度OSAHS患者血清尿酸浓度随着AHI的增加和缺氧程度的加重而增高,血清尿酸、肌酐水平的升高预示OSAHS患者可能存在一定程度的肾脏损害。

Objective To study the correlation of obstructive sleep apnea hypopnea syndrome（OSAHS） with serum uric acid（ UA）, serum creatinine（Scr） and blood urea nitrogen（Bun） concentrations. Methods 100 patients with moderate and severe OSAHS and 44 control subjects admitted into our hospital were recruited. The differences of the levels of UA, Scr and Bun among each group were analyzed. Also, the correlations between the apnea hypopnea index （AHI）, lowest saturation of blood oxygen （ LSaO2 ） and UA, Scr, Bun were analyzed. Results The levels of UA and Scr were significantly higher in groups with moderate or severe OSAHS than those in the control group （ P 〈 0.05 ）. UA was positively correlated with AHI （ P 〈 0.05 ）, but negatively correlated with LSaO2 （ P 〈 0.05 ）. Conclusion Concentrations of UA and Scr increase with AHI and the degree of anoxemia in patients with moderate and severe OSAHS. High levels of UA and Scr demonstrate that OSAHS is to a certain extent associated with kidney damage.