摘要
目的探讨不同胃疾病组织CDX2蛋白的表达及其在胃癌发生、分化中的作用,并且探讨幽门螺杆菌感染对CDX2蛋白表达的影响。方法随机选取300例胃黏膜标本,进行免疫组织化学染色。结果 CDX2蛋白表达在慢性萎缩性胃炎和胃癌组织高于浅表性胃炎(P=0.000),肠型胃癌高于弥漫型胃癌(P=0.000);CDX2蛋白表达阴阳性两组在不同胃疾病及不同分化的胃癌中H.pylori检出率无统计学差异(P>0.05)。结论 CDX2与胃癌的发生及肠型分化相关,CDX2蛋白的表达可能与H.pylori的感染无关。
Objective To investigate the expression of Caudal-type Homeobox Protein 2（CDX2） in various gastric diseases and the function of gastric carcinogenesis and differentiation;and study the influence of H.pylori infection on it.Methods Three hurdrend cases of gastric mucosa selected randomly were detected by immunohistochemistry.Results In chronic atrophic gastritis and gastric cancer,CDX2 expressed higher than that in superficial gastritis（P=0.000）.In the intestinal-type carcinoma,CDX2 expressed higher than that in the diffuse-type carcinoma（P=0.000）.In various gastric diseases and differentiation of gastric cancer,the detectable rate of H.pylori had no significant difference between CDX2 expressed positive and negative group.（P〉0.05）.Conclusion We found that CDX2 was involved in gastric carcinogenesis and the differentiation of intestinal-type adenocarcinoma.CDX2 expression may be independent of H.pylori infection.
出处
《医学研究杂志》
2011年第4期77-80,共4页
Journal of Medical Research
基金
黑龙江省自然科学基金资助项目(D200866)
