白癜风与HLA-DR4相关性研究的meta分析

Is Vitiligo Really Associated with HLA-DR4? A Meta-analysis of Literatures

目的:汇总文献资料,探索白癜风与HLA-DR4之间的相关性及影响因素。方法:检索国内外文献数据库,提取相关文献中的数据,经汇总后,进行荟萃(meta)分析。结果:共获得有关文献9篇,其中共有白癜风患者478例,对照5 733例。Meta分析显示HLA-DR4在白癜风患者中的频率显著增高(OR=1.76,P=0.007)。文献无发表偏倚,但文献间有异质性。回归分析显示HLA-DR4与白癜风的相关性受到各文献中研究对象的数量及种族差异的影响。结论:白癜风与HLA-DR4之间可能存在相关性。由于文献间异质性的存在,这一相关性仍需要大样本量的研究加以证实。

Objective：To study whether there is really correlation between vitiligo and HLA-DR4. Methods：We searched databases and identified 9 case-control studies describing the association between HLA-DR4 and vitiligo,including 478 cases and 5 733 controls.Results：A meta-analysis showed the frequency of HLA-DR4 was significantly higher in vitiligo patients than that of controls（OR=1.76,95% CI： 1.17-2.65）.The frequency of HLA-DR4 in non-segmental vitiligo patients was also higher than that of controls（OR=2.42,95% CI： 1.38-4.24）.Although no publication bias was found,a moderate or large heterogeneity was present among documents.Meta-regression analysis revealed the heterogeneity was sourced from the too small sample size in documents（P=0.019） and the ethnic difference（P=0.05）.Thus,caution is needed to understand the association between HLA-DR4 and vitiligo.Conclusion：For a reliable result,this issue should be further investigated by a study in a larger patient population with homogeneity.