期刊文献+

肝上皮样血管平滑肌脂肪瘤2例 被引量:2

Hepatic epithelioid angiomyolipoma: an analysis of two cases
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摘要 目的:探讨肝上皮样血管平滑肌脂肪瘤的病理诊断及鉴别诊断.方法:收集武钢总医院病理科2007-2009年手术切除肝上皮样血管平滑肌脂肪瘤标本2例,对2例肝上皮样血管平滑肌脂肪瘤相关临床资料、病理学特征及免疫组织化学进行观察分析并复习相关文献.结果:2病例均为女性,巨检境界较清楚,镜下见肿瘤主要由弥漫的上皮样细胞构成,排列呈不规则梁索状结构,瘤细胞圆形或多角形,核呈圆形或卵圆形,无明显异型性.免疫组织化学示HMB45、Melan-A和SMA均有阳性表达.结论:肝上皮样血管平滑肌脂肪瘤是极为罕见的间叶性肿瘤,其诊断及鉴别诊断主要依靠组织病理学及免疫组织化学. AIM:To investigate the clinicopathologic characteristics of hepatic epithelioid angiomyolipoma (EAML).METHODS:Two cases of hepatic EAML treated at General Hospital of Wuhan Iron and Steel Corporation from 2007 to 2009 were analyzed in this study.The clinicopathologic and immunohistochemical characteristics of the disease were described and the related literature was reviewed.RESULTS:Both patients are female.Both cases of hepatic EAML had clear boundaries.The tumors were characterized by diffused epithelioid neoplastic cells.The epithelioid cells were round with eosinophilic or clear cytoplasm,and few neoplastic cells showed cellular atypia.Immunohistochemically,the neoplastic cells were diffusely positive for HMB45,Melan-A and SMA.CONCLUSION:Hepatic EAML is a rare mesen-chymal neoplasm.The diagnosis and differentiatial diagnosis of EAML rely mainly on histopathology and immunohistochemistry.
出处 《世界华人消化杂志》 CAS 北大核心 2011年第10期1071-1074,共4页 World Chinese Journal of Digestology
关键词 肝肿瘤 上皮样平滑肌脂肪瘤 血管周上皮样细胞肿瘤 Hepatic neoplasms Epithelioid angiomyolipoma Perivascular epithelioid cell tumor
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参考文献11

  • 1Folpe AL, Mentzel T, Lehr HA, Fisher C, Balzer BL, Weiss SW. Perivascular epithelioid cell neoplasms of soft tissue and gynecologic origin: a clinicopathologic study of 26 cases and review of the literature. Am J Surg Pathol2005; 29:1558-1575.
  • 2Morioka M, Kinugawa K, Funabiki S, Matsuda T, Furukawa Y, Wani Y. Monotypic epithelioid angiomyolipoma of the kidney: a case report. Int J Urol 2006; 13:1240-1242.
  • 3Mai KT, Perkins DG, Collins JP. Epithelioid cell variant of renal angiomyolipoma. Histopathology 1996; 28:277-280.
  • 4Armah HB, Parwani AV. Perivascular epithelioid cell tumor. Arch Pathol Lab Med 2009; 133:648-654.
  • 5Park HK, Zhang S, Wong MK, Kim HL. Clinical presentation of epithelioid angiomyolipoma. Int J Urol2007; 14:21-25.
  • 6Zeng JP, Dong JH, Zhang WZ, Wang J, Pang XP. Hepatic angiomyolipoma: a clinical experience in diagnosis and treatment. Dig Dis Sci 2010; 55: 3235-3240.
  • 7毕卫群,陈静静,华辉,冉雯雯,李颖端,纪清连.肾脏上皮样血管平滑肌脂肪瘤的螺旋CT表现及病理对照研究[J].医学影像学杂志,2009,19(12):1591-1594. 被引量:12
  • 8Kato I, Inayama Y, Yamanaka S, Ohshiro H, Gomi K, Shirai S, Aoki I, Uemura H, Miyoshi Y, Kubota Y, Yao M, Nagashima Y. Epithelioid angiomyolipoma of the kidney. Pathol Int 2009; 59:3843.
  • 9Li T, Fan J, Qin LX, Zhou J, Sun HC, Wang L, Ye QH, Qiu SJ, Tang ZY. [A clinicopathologic study of hepatic angiomyolipoma]. Zhonghua Waike Zazhi 2009; 47:1536-1539.
  • 10王兆亮,朱建善,陈以明,王莉.肾脏上皮样血管平滑肌脂肪瘤的免疫组织化学检测[J].上海交通大学学报(医学版),2010,30(6):722-725. 被引量:10

二级参考文献23

  • 1安杰,成继民,陈玮,张文,刘艳丽.肾脏上皮样血管平滑肌脂肪瘤临床病理分析[J].罕少疾病杂志,2007,14(2):14-16. 被引量:6
  • 2刘晖,唐小筱,纪祥瑞,孙显露,刘勇,姜天福,梁军,唐丽瓯.肾上皮样血管平滑肌脂肪瘤——附4例报告及文献复习[J].中华肿瘤防治杂志,2007,14(14):1106-1108. 被引量:13
  • 3Eble JN, Sauter G, Epstein Jl, et al. WHO classification of tumours: pathology and genetics of tumours of the urinary system and male genital organs (world health organization classification of tumours) [ M ]. IARC Press: Lyon, 2004.65 - 69.
  • 4Flemming P, Lehmann U, Becker T, et al. Common and epithelioid variants of hepatic angiomyolipoma exhibit clonal growth and share a distinctive immunophenotype[J]. Hepatology,2000,32:213-217.
  • 5Makhlouf HR, Ishak KG, Shekar R, et al. Melanoma markers in angiomyolipoma of the liver and kidney: a comparative study[J]. Arch Pathol Lab Meal,2002,126:49- 55.
  • 6Huang KH, Huang CY, Chung SD, et al. Malignant epithelioid angiomyoliponm of the kidney[J]. J Fonnos Med Assoc,2007,106:51 - 54.
  • 7Acikalin MF, Tel N, Oner U, et al. Epithelioid angiomyolipoma of the kidney[J]. Int J Urol,2005,12:204- 207.
  • 8Cibas ES, Goss GA, Kulke MH, et al. Malignant epithelioid angiomyolipoma ( ' sarcoma ex angiomyolipoma' ) of the kidney: a case report and review of the literature [ J ]. Am J Surg Pathol, 2001,25 : 121 - 126.
  • 9Kim JK, Park SY, Shon JH, et al. Angiomyolipoma with minimal fat: differentiation from renal cell carcinoma at biphasic helical CT [ J]. Radiology, 2004,230: 677 - 684.
  • 10Kawaguchi KI, Oda Y, Nakanichi K, et al. Malignant transformation of renal angiomyolipoma-a case report[J]. Am J Surg Pathol,2002, 26:523 - 529.

共引文献19

同被引文献18

  • 1Tian-An Jiang, Qi-Yu Zhao, Miao-Yan Chen, Li-Jun Wang and Jian-Yang Ao Hangzhou, China Department of Ultrasonography, First Affiliated Hos- pital , Distance Education Center and Department of Pathology, First Affiliated Hospital , Zhejiang University School of Medicine, Hangzhou 310003, China.Diagnostic analysis of hepatic angiomyolipoma[J].Hepatobiliary & Pancreatic Diseases International,2005,4(1):152-155. 被引量:4
  • 2Zhao LJ, Yang YJ, Wu H, et at. Perivascular epithehoid cell tumor of the liver: a case report and literature review[ J]. Eur Rev Med Pharmacol Sci, 2013,17(12) :1665-1668.
  • 3Selvaggi F, Risio D, Claudi R, et al. Malignant PEComa: a case report with emphasis on clinical and morphological criteria [ J ]. BMC Surg, 2011,11:3.
  • 4Yang X, Li A, Wu M. Hepatic angiomyolipoma : clinical, imaging and pathological features in 178 cases[ J]. Med Oncol, 2013,30 ( 1 ) :416.
  • 5Yang CY, Ho MC, Jeng YM, et at. Management of hepatic angio- myolipoma [ J ]. J Gastrointest Surg, 2007,11 (4) :452-457.
  • 6Pea M, Bonetti F, Zamboni G, et al. Melanocyte-marker-HMB-45 is regularly expressed in angiomydipoma of the kidney [ J ]. Pathology, 1991,23(3) :185-188.
  • 7Bonetti F, Pea M, Martignoni G, et al. Cellular heterogeneity in lymphangiomyomatosis of the lung [ J ]. Httm Pathol, 1991,22 (7) :727-728.
  • 8Parfitt JR, Bella AJ, Izawa JI, et al. Malignant neoplasm of perivascular epithelioid ceils of the liver [ J ]. Arch Pathol Lab Med, 2006,130(8):1219-1222.
  • 9Vagefi PA, Eilers H, Hiniker A, et al. Liver transplantation for gi- ant hepatic angiomyolipoma [ J ]. Liver Transpl, 2011,17 ( 8 ) : 985-986.
  • 10Peng J, Yu B, Wang J, et al. An unresectable malignant perivas- cular epithelioid cell tumor resistant to multiple combined chemo- therapies:a unique case report [ J ]. J Pediatr Hematol Oncol, 2010,32(4) :136-138.

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