化疗药物性肝病65例临床分析

Clinical analysis on drug-induced liver disease caused by chemotherapy in 65 cases

目的:分析化疗所致药物性肝病的临床特点,以提高对该病的认识。方法:对从2008年1月-2009年12月根据Ma-ria诊断标准诊断为化疗所致药物性肝病65例进行回顾性分析。结果:常用化疗药物都可引起药物性肝病,主要临床表现为恶心、纳差41例(63.1%),乏力35例(53.8%),黄疸28例(43.1%),多数患者预后良好,治愈60例(92.3%)。结论:临床应重视化疗所致药物性肝病的预防、诊断和治疗。

OBJECTIVE To investigate the clinical characteristics of patients with drug-induced liver disease caused by chemotherapy. METHODS From January 2008 to December 2009,65 cases confirmed drug-induced liver disease caused by chemotherapy according to Maria criterion were retrospectively reviewed. RESULTS The common antineoplastics could induce liver disease. The principal clinical manifestation included nausea （ 63.1 % ）, fatigue （ 53.8% ）, jaundice （43. 1 % ）. Most patients （92. 3%）were cured with good prognosis. CONCLUSION The clinicians should draw attention to the diagnosis and therapy of drug-induced liver disease caused by chemotherapy.