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联合检测降钙素原与C反应蛋白水平的临床意义 被引量:4

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摘要 降钙素原(PCT)是由116个氨基酸组成的无激素活性的降钙素(calcitonin,CT)前体物。正常情况下PCT mRNA在甲状腺滤泡旁细胞粗面内质网内翻译成含141个氨基酸的前PCT进入内质网膜,经糖基化和特异酶的作用,生成PCT。产生PCT的主要部位在肝脏,其他如单核细胞、脾、肺或小肠的神经内分泌细胞也可以产生。内毒素可刺激降钙素原的释放。PCT来自定位于第11号染色体上(11P15,4)的单拷贝基因,该基因由2800个碱基对组成,
作者 王会琴 徐力
出处 《中国实用医刊》 2011年第11期F0003-F0004,共2页 Chinese Journal of Practical Medicine
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