脂肪酶转酯化和水解反应拆分薄荷醇的研究进展

Research progress of racemic menthol by lipase kinetic resolution

在拆分薄荷醇的研究中,脂肪酶因具有化学、区域和立体选择性以及来源广泛,价廉、操作简单而得到普遍应用。本文从脂肪酶拆分薄荷醇的转酯化、水解反应的工艺和影响因素等方面,分析了脂肪酶动力学拆分过程的转酯化和水解反应的催化路径和特点,指出脂肪酶拆分薄荷醇的最佳路径和工艺选择。综述了近10年来脂肪酶拆分消旋体薄荷醇的研究进展,特别综述了具有工业化前景的脂肪酶催化拆分和单元操作工艺的研究进展。同时展望了未来脂肪酶拆分薄荷醇的研究方向。

In the investigation of resolution of racemic menthol,lipase is generally used because lipase has chemistry-,region-,and stereo-selectivity,and the operation with lipase is noted for reliable source,low-cost,and simple procedure.The research progress of racemic menthol resolution by lipase in the past 0 years is reviewed.Especially,potential industrial applications of the lipase catalytic approach and unit operations are covered by analyzing the processes of trans-esterification,hydrolysis reaction and influence factors.The optimal pathway of resolution is achieved by analyzing resolution routes of menthol and alternatives of acyl agent for trans-esterification of menthol.Future investigations of the resolution of racemic menthol by lipase are discussed.