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PI3K/Akt细胞信号转导通路与肺纤维化 被引量：3

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摘要 肺纤维化疾病包括特发性肺纤维化、结节病、尘肺病、放射性肺纤维化等。尘肺病是目前我国最受关注的职业病,严重危害作业工人的健康,迄今仍缺乏有效的治疗药物,因此,研究肺纤维化的机制已成为一种迫切的需要。
作者 周华仕 鞠莉 贾振宇 张幸
机构地区 浙江省医学科学院
出处 《工业卫生与职业病》 CAS CSCD 北大核心 2011年第3期183-186,共4页 Industrial Health and Occupational Diseases
基金 浙江省自然科学基金(Y206563)
关键词 特发性肺纤维化 细胞信号转导通路 PI3K/AKT 放射性肺纤维化 纤维化疾病 作业工人 治疗药物 尘肺病
分类号 R135.2 [医药卫生—劳动卫生]
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参考文献20

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共引文献1

同被引文献49

  • 1宋康,夏永良,金晓莹,陈素珍,杨珺超,骆仙芳.虎杖对肺纤维化大鼠信号转导与转录活化子1表达的影响[J].中国中医药科技,2009,16(5):367-369. 被引量：8
  • 2张勇,张璟.PI3-K的激活在TGF-β_1诱导肾小管上皮细胞间质转分化过程中的作用[J].解放军医学杂志,2006,31(6):553-555. 被引量：8
  • 3Cantley L C. The phosphoinositide 3-kinase pathway [J]. Science, 2002, 296( 5573 ): 1655-1657.
  • 4Lu Y J, Azad N, Wang L, et al. Phosphatidylinosito-1 3-kinase/ akt regulates bleomycin-induced fibroblast proliferation and collagen production[J]. Am J Respir Cell Mol Bio, 2010, 42 (4): 432-441.
  • 5Xia H, Diebold D, Nho R, et al. Pathological integrin signaling enhances proliferation of primary lung fibroblasts from patients with idiopathie pulmonary fibrosis [J]. J Exp Med, 2008, 205(7): 1659-1672.
  • 6Kulkarni A A, Thatcher T H, Olsen K C, et al. PPAR-y ligands repress TGF~-induced myofihrohlast differentiation by targeting the PI3K/Akt pathway: implications for therapy of fibrosis [J/OL]. PLoS One, 2011, 6 ( 1 ): e15909 [2016-05-20]. http://dx.doi.org/10.1371/journal.pone.0015909.
  • 7Conte E, Fruciano M, Fagone E, et al. Inhibition of PI3K prevents the proliferation and differentiation of human lung fibroblasts into myofibrobalsts: the role of class I Pl10 isoforms [J/OL]. PLoS One, 2011, 6 ( 10 ): e24663. [2016-05-20]. http://dx.doi.org/lO.1371/journal.pone.O024663.
  • 8Runyan CE, Sehnaper HW, Poncelet AC. The Phosphatidylinositol 3-kinase/Akt pathway enhance Smad3-stimulated mesangial cell collagen I expression in response to transforming growth factor-betal [J 1. J Biol Chem, 2004, 279( 4 ): 2632.
  • 9冯莉,王献华.转化生长因子-β_1介导的ERK/MAPK信号通路与肺纤维化[J].中国煤炭工业医学杂志,2008,11(10):1621-1623. 被引量：5
  • 10陈小囡,田菊霞,陈河,徐小冬,朱婉萍,王灵均.红豆杉活性成分巴卡亭Ⅲ对大鼠肺纤维化的干预作用[J].浙江中医杂志,2009,44(3):192-193. 被引量：7

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工业卫生与职业病
2011年 第3期

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