遗传密码之父--尼伦伯格被引量：2

下载PDF

导出

摘要 1953年，沃森（J．Watson）和克里克（F．Crick）提出DNA双螺旋结构，从而确立了作为遗传信息载体的DNA成为分子生物学研究的基础，但DNA如何发挥生物学功能尚不得而知。1958年，克里克提出著名的中心法则，认为DNA中遗传信息最终转化为蛋白质的结构信息。

作者郭晓强

机构地区白求恩军医学院生化教研室

出处《科学》北大核心 2011年第3期50-53,共4页 Science

关键词尼伦伯格遗传密码神经生物学诺贝尔奖

参考文献9

1Nirenberg M W,Matthaei J H. The dependence of cell-free protein synthesis in E. coli upon naturally occurring or synthetic: polyribonucleotides. Proc Natl A cad Sci USA, 1961,47: 1588.
2郭晓强.菲利普·里德[J].遗传,2007,29(7):777-778. 被引量：1
3Nirenberg M, Leder P. RNA codewords and protein systhesis. The effect of trinucleotides upon the binding of SRNA to nbosomes. Science, 1964,145 : 1399.
4Nirenherg M. Historical review : Deciphering the genetic code a personal account. Trends Biochem Sci, 2004,29 ( 1 ) : 46.
5Nelson P, Ruffner W, Nirenberg M. Neuronal tumor cells with excitable membranes gown in vitro. Proc Natl Acad Sci USA, 1969,64(3) : 1004.
6Regis E. The forgotten code cracker. Sci A m, 2007,297 (5) :50.
7Scolnick E. Obituary:Marshall Nirenberg 1927-2010. Cell,2010,140(4) : 450.
8Caskey C T. Obituary : Marshall Nirenberg ( 1927-2010). Nature, 2010, 464(7285) : 132.
9Leder P. Retrospective. Marshall Warren Nirenberg ( 1927-2010 ). Science, 2010,327 ( 5968 ) : 972.

1Nirenberg M,Leder P.DNA codewords and protein systhesis.The effect of trinucleotides upon the binding of SRNA to ribosomes.Sciences,1964,145:1399-1407.
2Seidman JG,Max EE,Leder P.A kappa-immunoglobulin gene is formed by site-specific recombination without further somatic mutation.Nature,1979,280(5721):370-375.
3Stewart TA,Pattengale PK,Leder,P.Spontaneous mammary adenocarcinomas in transgenic mice that carry and express MTV/myc fusion genes.Cell,1984,38(3):627-637.
4Tepper RI,Coffman RL,Leder P.An eosinophil-dependent mechanism for the antitumor effect of interleukin-4.Science,1992,257(5069):548-551.
5郭晓强.拉斯克基础医学奖简介(2)[J].生物学通报,2003,38(10):59-60. 被引量：6

1RAJBHANDARY U L. Har Gobind Khorana (1922--2011) [J]. Nature, 2011, 480(7377): 322,.
2SAKMAR T P. Har Gobind Khorana (1922--2011): pioneering spirit [J]. PLoS Biol, 2012, 10(2): e1001273.
3CARUTHERS M, RETROSPECTIVE W R. Har Gobind Khorana (1922--2011) [J]. Science, 2011,334(6062): 1511.
4MOFFATT J G, KHORANA H G. The total synthesis of coenzyme A [J]. J Am Chem Soc, 1959, 81(5): 1265-1265.
5KHORANA H G, 1313CHI H, GHOSH H, et al. Polynucleotide synthesis and the genetic code [J]. Cold Spring Harb Symp Quant Biol, 1966, 31: 39-49.
6SHAMPO M A, KYLE R A. Har Gobind Khorana--Nobel Prize for physiology or medicine [J]. Mayo Clin Proc, 2006,81(3): 284.
7AGARWAL K L, BI]CHI H, CARUTHE RS M H, et al. Total synthesis of the gene for an alanine transfer ribonucleie acid from yeast [J]. Nature, 1970, 227(5253): 27-34.
8KRESGE N, SIMONI R D, HILL R L. Total synthesis of a tyrosine suppressor tRNA: the work of H. Gobind Khorana [J]. J Biol Chem, 2009, 284(22): eS.
9KHORANA H G. Total synthesis of a gene [J]. Science, 1979, 203(4381): 14-625.
10DUNN R, MCCOY J, SIMSEK M, et al. The bacteriorhodopsin gene [J]. Proc Natl Acad Sci USA, 1981, 78(11): 6744-6748.

1李亮,张晓红,陆岩,陈慧霞.课程思政背景下高校生物学专业开展生物学史教育的思考[J].高校生物学教学研究（电子版）,2022,12(3):29-32. 被引量：3
2郭晓强,李岩异.RNA研发简史:从微不足道到无比重要[J].自然杂志,2022,44(6):480-490.

科学

2011年第3期

内容加载中请稍等...