受体酪氨酸激酶c—Met与肺癌关系研究进展

Research progress on relationship between receptor tyrosine kinase c-Met and lung cancer

受体酪氨酸激酶c-Met是由原癌基因c-Met所编码的,具有控制细胞生长、侵袭和抗凋亡等生物学作用.c-Met的异常表达与肺癌的发生、发展及恶性生物学行为关系密切.针对c-Met通路的靶向治疗是目前肺癌治疗的新热点.本文将就受体酪氨酸激酶c-Met的生物学特征、与肺癌的关系及其在肺癌治疗中的应用作一综述.

Receptor tyrosine kinase c-Met is encoded by c-Met proto-oncogene. It plays an important role in cell growth,invasion,anti-apoptosis,and other biological effects. The abnormal expression of c-Met is closely related with the development and malignant biological behaviour of lung cancer. The targeted therapy for c-Met pathway is the new hot spot of lung cancer treatment. This paper reviews biological characteristics of receptor tyrosine kinase c-Met,its relationship with lung cancer,and the application in treatment of lung cancer.