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Go/NoGo实验下NoGo-N2、P3效应分析 被引量：1

NoGo-N2、P3 Effect Analysis in Go/NoGo Paradigm
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摘要 在Go/NoGo实验范式下用事件相关电位研究反应抑制脑机制时,传统的研究结果显示在大脑前额区NoGo任务下的N2、P3成份分别相对于Go任务有负向、正向的偏移,即NoGo-N2效应和NoGo-P3效应。由于在Go任务中行为反应引发了运动相关成份的叠加效果,可能导致真实的NoGo-N2、P3效应被掩盖。为了恢复真实NoGo-N2、P3效应,采用刺激、反应成份分解算法消除Go条件下运动相关成份的影响。结果表明,NoGo-P3效应来自运动相关成份的叠加效果,有可能与反应抑制过程无关,而NoGo-N2效应则反映了反应抑制过程。 During the study of brain mechanism of response inhibition using event-related potentials（ERP） under Go/NoGo experiment paradigm,traditional research results have shown that ERP following Go/NoGo tasks show two major differences between Go and NoGo trials at the prefrontal area.One is a negative deflection of N2 component in NoGo trials compared to Go trials,and the other is a positive deflection of P3 component in NoGo trials compared to Go trials.They are also named NoGo-N2 effect and P3 effect.The overlap of movement-related component deriving behavior response on Go trials may make true NoGo-N2 effect and P3 effect to be masked.In order to recover true NoGo-N2 effect and P3 effect,stimulus and response components decomposition method is applied to eliminate the influence of motor-related component in Go trials.Results show that NoGo-P3 effect is resulted from overlap of motor-related component and it may not relate to response inhibition processes,while NoGo-N2 effect is related to response inhibition processes.
作者 尹刚 刘铁军
机构地区 电子科技大学神经信息教育部重点实验室
出处 《电子科技大学学报》 EI CAS CSCD 北大核心 2011年第3期465-469,共5页 Journal of University of Electronic Science and Technology of China
基金 国家自然科学基金(60736029 60701015)
关键词 事件相关电位 NoGo-N2效应 NoGo-P3效应 反应抑制 刺激 反应 event-related potentials NoGo-N2 effect NoGo-P3 effect response inhibition stimulus response
分类号 TP202.1 [自动化与计算机技术—检测技术与自动化装置]
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参考文献16

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同被引文献15

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电子科技大学学报
2011年 第3期

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