香砂六君子汤合乌药散加减中药配方颗粒治疗小儿腹痛临床观察

Clinical Observation of 168 Cases of Infantile Abdominal Pain Treated with the Granules and Decoction Prepared with Modified Xiangsha Liujunzi Tang and Wuyao San

目的评价香砂六君子汤合乌药散加减中药配方颗粒治疗小儿腹痛的有效性和安全性。方法采用随机、对照法将患儿分为两组。治疗组78例,予以香砂六君子汤合乌药散加减中药配方颗粒治疗;对照组90例,予以香砂六君子汤合乌药散加减中药饮片汤剂作为对照治疗。两组均治疗21 d,观察两组治疗前后临床症状、生命体征及三大常规、肝肾功能的改善情况。结果治疗组76例,对照组86例完成治疗。治疗21 d后,治疗组总有效率为92.11%,对照组总有效率为89.53%。两组各临床症状改善情况比较,经χ2检验,χ2=0.317,P>0.05,两者疗效无统计学差异。结论香砂六君子汤合乌药散加减免煎配方颗粒对小儿腹痛具有治疗作用,与传统中药饮片汤剂疗效相当,并且安全、无不良反应,值的临床推广使用。

Objective To evaluate the effectiveness and safety of the granules and decoction prepared with modified xiangsha liujunzi tang and wuyao san in the treatment of infantile abdominal pain.Methods The patients were randomized into two groups.78 cases in a treatment group were treated with the granules prepared with modified xiangsha liujunzi tang and wuyao san.90 cases in a control group were treated with the decoction prepared with modified xiangsha liujunzi tang and wuyao san.All the cases in two groups were treated for 21 days.The clinical symptoms,life physical signs and the improvements of three major routine examination,liver and kidney function were observed before and after treatment in two groups.Results 76 cases in treatment group and 86 cases in control group finished the treatment.In 21 days of treatment,the total effective rate was 92.11% in treatment group and was 89.53% in control group.By chi-square test,there was no statistical difference significance,χ2=0.317,P0.05 in comparison of the improvements in clinical symptoms between two groups.Conclusion The therapeutic effect of the granules prepared with modified xiangsha liujunzi tang and wuyao san is same as the traditional herbal decoction.This granule form of Chinese medicine is safe and no adverse reactions and it deserves to be promoted in clinical practice.