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sRAGE在配体-RAGE轴介导的多种病变中的作用 被引量：3

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摘要 晚期糖基化终产物受体（receptor for advanced glycationendproducts,RAGE）及其配体相互作用形成配体-RAGE轴,激活细胞内多条信号通路,与一系列疾病的发生和发展存在密切联系。其致病方式主要为增强氧化反应,改变细胞功能,导致局部组织微环境发生变化,加强免疫应答和炎症反应。然而,血浆和组织中存在着一种特殊的RAGE亚型,
作者 王达 黄巧冰
机构地区 南方医科大学第一临床医学院 南方医科大学基础医学院病理生理教研室
出处 《广东医学》 CAS CSCD 北大核心 2011年第9期1202-1204,共3页 Guangdong Medical Journal
基金 国家自然科学基金资助项目(编号:30771028)
关键词 配体 晚期糖基化终产物受体 病变 介导 局部组织 强免疫应答 相互作用 信号通路
分类号 R392.11 [医药卫生—免疫学]
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  • 1张美燕,郑兴.急性心肌梗死与基质金属蛋白酶-9表达[J].临床心血管病杂志,2007,23(12):881-883. 被引量：2
  • 2刘华,李学旺,李航.晚期糖基化终末产物及其受体与糖尿病肾病[J].国外医学（泌尿系统分册）,2005,25(5):658-661. 被引量：4
  • 3Yellon DM, Hausenloy DJ. Myocardial reperfusion injury. N Engl J Med 2007; 357: 1121-1135.
  • 4Vinten-Johansen J. Involvement of neutrophils in the pathogenesis of lethal myocardial reperfusion injury. Cardiovasc Res 2004; 61: 481-497.
  • 5Kislinger T, Fu C, Huber B, Qu W, Taguchi A, Yan SD, et al. N(epsilon)-(carboxymethyl) lysine modifications of proteins are ligands for RAGE that activate cell signaling pathways and modulate gene expression. J Biol Chem 1999; 274: 31740-31749.
  • 6Hofmann MA, Drury S, Fu C, Qu W, Taguchi A, Lu Y, et al. RAGE mediates a novel proinflammatory axis: a central cell surface receptor for S 100/calgranulin polypeptides. Cell 1999; 97: 889-901.
  • 7Goldin A, Beckman JA, Schmidt AM, Creager MA. Advanced glycation end products: sparking the development of diabetic vascular injury. Circulation 2006; 114: 597-605.
  • 8Andrassy M, Volz HC, Igwe JC, Funke B, Eichberger SN, Kaya Z, et al. High-mobifity group box-1 in ischemia- reperfusion injury of the heart. Circulation 2008; 117: 3216-3226.
  • 9Tsoporis JN, Marks A, Haddad A, Dawood F, Liu PE Parker TE S100b expression modulates left ventricular remodeling after myocardial infarction in mice. Circulation 2005; 111 598-606.
  • 10Aleshin A, Ananthakrishnan R, Li Q, Rosario R, Lu Y, Qu W, et al. RAGE modulates injury consequent to LAD infarction via impact on JNK and STAT signaling in a murine model. Am J Physiol Heart Circ Physiol 2008; 294: H1823-H1832.

共引文献21

同被引文献23

  • 1蒋雨平,王坚,丁正同,邬剑军,陈嬿.原发性帕金森病的诊断标准(2005年)[J].中国临床神经科学,2006,14(1):40-40. 被引量：155
  • 2Yang SJ, Kim S, Hwang SY, et al. Association between sRAGE, esRAGE levels and vascular inflammation: analysis with 18F-fluorodeoxyglucose positron emission tomography [J]. Atherosclerosis, 2012,220 (2) : 402 - 406.
  • 3Sakurai S,Yonekura H, Yamamoto Y, et al. Identification of a novel AGE-capturable soluble variant of the RAGE in hu- man sera[J]. Inter Con Ser, 2002,1254 : 163- 167.
  • 4Bianchi R, Giambanco I, Donato R. S100B/RAGE-depend- ent activation of microglia via NF- kappaB and AP- 1 Co- regulation of COX- 2 expression by S100B, IL- 1beta and TNF-alpha[J]. Neurobiol Aing,2010,31(4) :665-677.
  • 5Nakamura K,Yamagishi S, Nakaura Y, et al. Telmisartan in hibits expression of a receptor for advanced glycation end prod- ucts in giotensinexp sed endothelial cells and decreases serum levels of soluble rage in patients with essensial hypertension [J]. Microvasc Res,2005,70(3) : 137- 141.
  • 6Hzecka J. Serum-soluble receptor for advanced glycation end product levels in patients with amyotrophic lateral sclerosis [J]. Acta Neurol Scand,2009,120(2):119-122.
  • 7Ma L, Nicholson LF. Expression of the receptor for advanced glyeation end products in Huntington's disease caudate nucleus [J] . Brain Res,2004,1018(1) :10-17.
  • 8Sasaki N, Takeuchi M, Chowei H, et al. Advanced glycation end products and their receptor(RAGE) in the brain of pa- tients with Creutzfeldt-Jakob disease with prion plaques[J]. Neurosci lett,2002,326(2) :117-120.
  • 9Casula M, lyer AM, Spliet WG, et al. Toll-like receptor sig- naling in amyotrophic lateral sclerosis cord tissue[J] . Neuro- science, 2011,179 : 233-243.
  • 10Ghidoni R,Benussi L,Glionna M,et al. Decreased plasma levels of soluble receptor for advanced glycation end products in mild cognitive impairment [J]. Neural Transm, 2008, 115 ( 7 ) : 1 047-1 050.

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广东医学
2011年 第9期

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