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Smurf 2对TGF-β通路的调节 被引量：3

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摘要 TGF-β是一类相关蛋白超家族成员,在胚胎发育、维持成人组织内环境稳定和多种疾病的发病中起决定性作用。目前TGF-β1/Smad信号转导通路已成为国际研究热点。最近发现泛素-蛋白酶体途径中的泛素连接酶Smurf 2参与了TGF-β1/Smad信号通路中的多个环节,产生即有正调节又有负调节的双重作用。
作者 刘怡菲 刘先哲
机构地区 三峡大学医学院 三峡大学人民医院科研科 湖北省宜昌市第一人民医院心血管内科
出处 《广东医学》 CAS CSCD 北大核心 2011年第9期1207-1208,共2页 Guangdong Medical Journal
关键词 TGF-β1 信号转导通路 负调节 泛素-蛋白酶体途径 SMAD信号通路 泛素连接酶 家族成员 相关蛋白
分类号 R575.2 [医药卫生—消化系统]
  • 相关文献

参考文献20

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二级参考文献10

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共引文献2

同被引文献46

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引证文献3

二级引证文献7

广东医学
2011年 第9期

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