罗格列酮联合美沙拉嗪治疗溃疡性结肠炎对IL-1β、TNF-α的影响

Influence of Rosiglitazone and Mesalazine Combination for Ulcerative Colitis on IL-1β and TNF-α

目的探讨罗格列酮联合美沙拉嗪治疗轻中度活动期溃疡性结肠炎(UC)对IL-1β、TNF-α的影响。方法选择活动期轻中度UC患者52例,随机分为3组,分别口服罗格列酮加美沙拉嗪(治疗组),口服美沙拉嗪(对照组1),口服美沙拉嗪加地塞米松灌肠(对照组2),临床治疗4周后观察血清IL-1β、TNF-α的变化。结果各组治疗后IL-1β和TNF-α水平均下降,与治疗前比较差异均有统计学意义(P均<0.05),并且治疗组下降的幅度较对照组明显(P<0.05),但对照组之间差异无统计学意义(P>0.05)。结论罗格列酮联合美沙拉嗪对UC有保护作用,效果优于单独应用美沙拉嗪或美沙拉嗪联合激素灌肠,其机制可能是调整机体免疫平衡。

Objective To investigate the influence of rosiglitazone and mesalazine combination on IL-1β and TNF-α in mild to moderate active ulcerative colitis.Methods 52 patients with mild to moderate active ulcerative colitis were enrolled our study,who were randomly divided into three groups：treatment group（n=18）with rosiglitazone and mesalazine oral,control group1（n=17） with mesalazine oral only,control group 2（n=17） with mesalazine oral and dexamethasone retention enema.After 4weeks,the changes of IL-1βand TNF-α in the serum of the 3 groups were detected by enzyme-linked immunosorbent assay（ELISA）.Results The levels of IL-1β and TNF-α in 3 groups decreased significantly after treatment（P0.05）.The descent in treatment group was more significantly than those of the two control groups（P0.05）,but the difference between the two control groups was not significant（P0.05）.Conclusion The combination of rosiglitazone and mesalazine has a protective effect on UC.The effectiveness is better than that of mesalazine oral only or mesalazine oral and dexamethasone retention enema.The mechanism might come by regulating the immunologic balance.