急性脑梗死患者C反应蛋白变对与颈动脉粥样硬化的影响研究

Acute Cerebral Infarction C-reactive Protein Changes with Carotid Atherosclerosis

目的探讨急性脑梗死患者血C反应蛋白(CRP)与颈动脉粥样硬化的关系。方法对50例急性脑梗死患者和46例正常对照组进行观察。采用速率散射比浊法测定血CRP含量;检测颈动脉内膜-中膜厚度(IMT),观察颈动脉粥样斑块。结果急性脑梗死患者血CRP含量、颈动脉IMT和粥样斑块数较对照组明显增加;血CRP水平与临床神经功能缺损评分、吸烟指数、颈动脉IMT及斑块数呈正相关。结论 CRP作为炎性指标可能在动脉粥样硬化的发生和发展中起了重要的作用;血CRP水平可作为急性脑梗死患者病情轻重和预后的评价指标。

Objective Patients with acute cerebral infarction C-reactive protein（CRP） and carotid atherosclerosis relationship.Methods 50 cases of acute cerebral infarction and 46 normal controls were observed.By rate nephelometry determination of blood CRP levels;carotid artery intima media thickness（IMT）,carotid artery plaque.Results Serum CRP levels in patients with acute cerebral infarction,carotid artery IMT and plaque number increased significantly compared with the control group;blood CRP levels and clinical neurological deficit score,smoking index,carotid IMT and plaque number were positively correlated.Conclusion CRP as inflammatory markers may facilitate the occurrence of atherosclerosis and development play an important role;blood CRP levels can be used as the severity of acute cerebral infarction and prognosis evaluation.