水源水中四氯化碳最高容许浓度的研究

Studies of Maximum Allowable Concentration of Carbon Tetrachloride in Source of Drinking-water

四氯化碳经口中毒动物试验表明:急性中毒引起肝细胞膜脂质过氧化反应,P-450降低,SGPT 和肝甘油三脂增高,并且确认脂质过氧化是四氯化碳中毒重要起始反应;慢性中毒阈剂量为0.2mg/kg,形态学上的改变为肝细胞脂肪变、坏死和增生、亚细胞结构粗面内质网颗粒脱落,空泡反应,最大无作用剂量为0.02mg/kg,换算成浓度值为0.4mg/L,加上必要的安全系数,建议水源水中四氯化碳最高容许浓度为0.004mg/L。

The studies of carbon tetrachloride(CC14)in vivo orally showed tha(?) liver cell membrane lipid peroxidation was induced by acute toxicity and confirmed as an important initial step in tetrachloride hepatotoxicity;the decrease of cytochrome P-450 and the increase of SGPT and liver triglyce- ride were also found.Chronic threshold dose was 0.2mg/kg of CC14.There were changes of cell lipoidosis,necrosis,proliferation,vacuolar degenera- tion and loss of ribosome granule from rough endoplasmic reticulum in morphology.The maximum-no effective dose of CC14 was 0.02mg/kg, which was exchanged for concentration value and added a necessary safty coefficient.It is suggested that the Maximum Allowable Concentration of CC14 in source of drinking-water be 0.004mg/L.