经皮二尖瓣球囊扩张术治疗老年人二尖瓣狭窄的临床观察

Evaluation of the efficacy and safety of percutaneous balloon mitral valvuloplasty in elderly patients with mitral stenosis

目的探讨经皮二尖瓣球囊扩张术（PBMV）治疗老年人二尖瓣狭窄的疗效、安全性及并发症的预防。方法采用改良的房间隔定位法及运用跨二尖瓣技术对老年二尖瓣狭窄患者行逐步球囊扩张。手术前后分别记录即刻左心房压、肺动脉平均压、二尖瓣跨瓣压差及二尖瓣口面积，并进行手术后随访。结果PBMV有效扩大了二尖瓣口面积，与术前比较，术后左心房压下降[分别为（25．3±6．7）mmHg（1mmHg=0．133kPa）与（16．4±5．8）mmHg]、二尖瓣跨瓣压下降[分别为（17．6±6．7）mmHg与（6．8±2．9）mmHg]、肺动脉压下降[分别为（38．6±12．1）mmHg与（29．2±9．8）mmHg]，二尖瓣口面积增加[分别为（1．05±0．22）cm2。与（1．61±0．38）cm2]，心功能明显改善，差异均有统计学意义（P〈0．05或P〈0．01）。随访结果表明，PBMV疗效稳定。结论PBMV操作技术的改进能明显改善老年患者二尖瓣狭窄症状，显著降低手术的并发症。

Objective To evaluate the efficacy and safety of the improved percutaneous balloon mitral valvu[oplasty （PBMV） in elderly patients with mitral stenosis. Methods Elderly patients with severe mitral stenosis received an improved PBMV which included a modified way of atrial septal puncture and technique across the mitral valve. The left atrial pressrue （LAP）, mean pulmonary pressure （MPA）, mean gradient across the mitral value （MPG） and mitral valve area （MVA） were recorded and compared before and after the operation. Long term follow up were made. Results After operation, the LAP decreased[（25.3±6.7） mm Hg vs. （16.4±5.8） mm Hg,1 mm Hg= 0. 133 Kpa], MPG decreased [（17.6±6.7） mm Hg vs. （6.8±2.9） mm Hg], MPA decreased [（38.6 ±12.1） mm Hg vs. （29.2±9.8） mm Hg], MVA increased [（1.05±0.22）cm2 vs. （1.61±0.38） cm2 and the New York heart association heart function classification improved. The follow up result showed that the effect of PBMV was constant. Conclusions Improved PBMV may be an effective and safe measure for patients with mitra stenosis.