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Brn3族转录因子对视网膜神经节细胞发育分化调控作用的研究进展

Recent advances in Brn3 family transcription factor regulation on retinal ganglion cells development
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摘要 Brn3转录因子家族成员Brn3a、Brn3b和Brn3c广泛作用于中枢神经系统的发育分化过程,在胚胎期和成体视网膜神经节细胞中均有大量的表达。通过基因敲除技术研究发现,Brn3族转录因子成员的缺失将造成视网膜神经节细胞明显的发育缺陷,说明Brn3族成员是视网膜神经节细胞正常发育分化的重要调控因素。本文将对Brn3族转录因子在视网膜神经节细胞发育分化中的调控作用及其研究进展进行综述。 Brn3 family transcription factors（Brn3a,Brn3b and Brn3c）play an essential role in central nervous system development,their expression are largely found in embryonic and adult retinal ganglion cells（RGC）.According to knockout study,deletion of Brn3 members will result in the significant deficiency of RGC,and seem to be the key factors for RGC development.This article reviews the recent advances in studies on Brn3 family transcription factor regulation on RGC development.
作者 黄倞 胡芳 曾祥云
机构地区 江西省人民医院眼科 南昌大学第一附属医院眼科 赣南医学院第一附属医院眼科
出处 《眼科新进展》 CAS 北大核心 2011年第5期488-489,496,共3页 Recent Advances in Ophthalmology
基金 国家自然科学基金资助(编号:81060081) 江西省自然科学基金资助(编号:2010JX02326)~~
关键词 Brn3 视网膜神经节细胞 基因敲除模型 基因调控 Brn3； retina ganglion cells； gene knockout； gene regulation
分类号 R774.1 [医药卫生—眼科]
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2011年 第5期

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