摘要
心力衰竭时交感神经兴奋性增加,使血浆游离脂肪酸浓度增高,引起胰岛素抵抗、葡萄糖氧化减少、游离脂肪酸氧化增加,导致能量产生减少、氧自由基和炎症介质产生增加,均加剧心力衰竭。肾上腺素β受体拮抗药、曲美他嗪、雷诺嗪、哌克昔林、二甲双哌等是目前心力衰竭代谢治疗中研究最多的药物。
The hyperadrenergic state of heart failure can cause the increase of plasma free fatty acid, insulin resistance and decrease of glucose oxidation,result in the decrease of energy production,increase of free radical generation and inflammatory markers,and thereby,make heart failure worse.Adrenergic beta receptor antagonists,trimetazidine,ranolazine,perhexiline and metformin were currently paid more attention in the study of metabolic therapy for heart failure.
出处
《中国新药与临床杂志》
CAS
CSCD
北大核心
2011年第4期241-244,共4页
Chinese Journal of New Drugs and Clinical Remedies
关键词
心力衰竭
充血性
代谢
葡萄糖
脂肪酸类
非酯化
药物疗法
heart failure
congestive
metabolism
glucose
fatty acid
nonesterified
drug therapy
