摘要
间充质干细胞（Mesenchymalstem cell，MSC）是一种中胚层起源的具有自我更新和多向分化潜能的异质性细胞群体。在体外培养时贴壁生长，具有成纤维细胞样形态和克隆形成能力，并能够典型地分化为成骨细胞、软骨细胞和脂肪细胞最初的MSC主要是从骨髓中分离获得，然而目前已证明从脂肪组织、真皮、肌肉、肌腱、胎盘、脐带、外周血和脐血等几乎所有结缔组织中都可分离得到。
出处
《中华血液学杂志》
CAS
CSCD
北大核心
2011年第5期355-358,共4页
Chinese Journal of Hematology
参考文献36
-
1Horwilz EM, le Blanc K, Dominici M, et al. Clarification of the nomenclature for MSC: The International Society for Cellular Ther- apy position statement. Cytotherapy, 2005,7: 393-395.
-
2da Silva-Meirelles L, Chagastelles PC, Nardi NB,et al. Mesenehy- real stem cells reside in virtually all postnatal organs and tissues. J Cell Sci, 2006, 119:2204-2213.
-
3Jiang XX, Zhang Y, Liu B, et al. Human mesenchymal stem cells inhibit differentiation and function of monocyle-derived dendritic cells. Blood,2005, 105:4120-4126.
-
4Nauta AJ, Kruisselbrink AB, Lurvink E, et al. Mesenchymal stem cells inhibit generation and function of both CD34 +-derived and monocyte-derived dendritic cells. J Immunol, 2006, 177: 2080- 2087.
-
5Li H, Guo ZK, Jiang XX, et al. Mesenchymal stem cells alter mi- gralory property of T and dendritic cells to delay the development of murine lethal acute graft-venus-host disease. Stem Cells, 2008,26:2531-2541.
-
6Uccelli A, Morena L, Pistoia V. Mesenchymal stem cells in health and disease. Nature, 2008,8:726-736.
-
7Aggarwal S, Pittenger MF. Human mesenchymal stem cells modu- late allogeneic immune cell responses. Blood, 2005,105.. 1815- 1822.
-
8Beyth S, Borovsky Z, Mevorach D, et al. Human mesenchymal stem cells alter antigen-presenting cell maturation and induce T-cell unresponsiveness. Blood,2005, 105: 2214-2219.
-
9Zhang W, Ge W, Li C, et al. Effects of mesenchymal stem cells on differentiation, maturation, and function of human monocyte-de- rived dendritic cells. Stem Cells Dev, 2004,13:263-271.
-
10Spaggiari GM, Capobianco A, Becchetti S,et al. Mesenchymal stem cell- natural killer cell interactions: evidence that activated NK cells are capable of killing MSCs, whereas MSCs can inhibit IL-2-induced NK-cell proliferation. Blood, 2006, 107: 1484- 1490.
同被引文献50
-
1董巧凤,贺韦东,尹哲,王迎雪,李丽珍,郭成山.骨髓间充质干细胞的体外扩增及其对T淋巴细胞产生IFN-γ和IL-10的影响[J].现代免疫学,2007,27(2):140-144. 被引量：17
-
2杨光忠 陈文明.间充质干细胞的免疫调节功能.中国全科医学,2009,12(8):1547-1547.
-
3Alhadlaq A,Mao JJ. Mesenchymal stem cells : isolation and thera-peutics [J]. Stem Cells Dev,2004,13 :436-448.
-
4Le Blanc K, Pittenger M. Mesenchymal stem cells: progress to-ward promise[ J]. Cytotherapy,2005 ,7(1) :36-45.
-
5Beyer Nardi N,da Silva Meirelles L. Mesenchymal stem cells:iso-lation ,in vitro expansion and characterization[ J]. Handb ExpP-harmacol,2006,174 :249-282.
-
6Roobrouck VD, Ulloa-Montoya F ,Verfaillie CM. Self-renewal anddifferentiation capacity of young and aged stem cells [ J ]. ExpCellRes,2008, 314(9):1937-1944.
-
7Petsa A, Gargani S, Felesakis A, et al. Effectiveness of proto-col for the isolation of Wharton Jelly stem cells in large-scaleapplications[ J]. In Vitro Cell Deve Biol Animal,2009, 45(10):573-576.
-
8Shetty P, Cooper K, Viswanathan, C. Comparison of proliferativeand multilineage differentiation potentials of cord matrix, cordblood, and bone marrow mesenchymal stem cells [ J]. Asian JTransfus Sci,2010, 4(1) :14-24.
-
9Stolzing A, Jones E,McGonagle D,et al. Age-related changes inhuman bone marrow-derived mesenchymal stem cells : conse-quences for cell therapies [ J ]. Mech Ageing Dev, 2008, 129(3):163-173.
-
10Xu J, Liao W, Gu D, et al. Neural ganglioside GD2 identifies asubpopulation of mesenchymal stem cells in umbilical cord [ J ].Cell Physiol Biochem, 2009,23(4-6) : 415424.
引证文献3
-
1黄阿雷,朱从元,杨军,李建平.间充质干细胞的体外免疫特性和机制[J].中国现代手术学杂志,2012,16(5):396-400.
-
2马倩玉,沈心,龚姝婧,黄施倩,许从峰.间充质干细胞的生物学调控及其在骨关节疾病中的应用[J].生命的化学,2018,38(2):207-212. 被引量：2
-
3金丽娟,汪玉海.携带Ad-HGF的脐血间充质干细胞对烧伤后大鼠体内炎症因子的影响[J].宁夏医科大学学报,2019,41(7):654-657. 被引量：1
二级引证文献3
-
1王佳.脐带间充质干细胞对CTX导致的药物性肝损伤大鼠的治疗作用[J].中国实用医药,2020,15(30):6-9.
-
2王旭杰,王妙然,张蕊,张雪雪,李秋艳.“先天之精”干细胞与中医学理论相关性探析[J].西部中医药,2022,35(6):60-63. 被引量：2
-
3徐小雪,陈梦梦,邹伟,张炳强.间充质干细胞对肿瘤微环境的调控[J].生命的化学,2022,42(1):34-40.
-
1朱勇,金伯泉,孙忱,刘雪松,赵宁,陈慰峰.用7TD_1细胞检测IL-6生物学活性方法的改良[J].上海免疫学杂志,1992,12(2):106-108. 被引量：4
-
2李东至.细胞凋亡与胎盘CELL DEATH AND PLACENTA[J].免疫学杂志,1999,15(2):135-137. 被引量：5
-
3冯德鹏,李雪莉,范炎.脐血间充质干细胞的研究进展[J].国际老年医学杂志,2010,31(5):234-237. 被引量：3
-
4唐美仪,董再珍,王龙.甲状腺激素对小鼠免疫功能的调节作用[J].生理学报,1991,43(1):60-66. 被引量：4
-
5李向明.皮肤老化的原因,临床表现及其控制（二）真皮[J].北京日化,1997(4):27-32.
-
6武宇辉（综述）,李成荣,李秋（审校）.微小RNA在脓毒症中免疫调控的研究进展[J].国际儿科学杂志,2012,39(1):49-53. 被引量：4
-
7缪晓辉,徐仁宝.FcγR免疫学功能与临床[J].国外医学（生理病理科学与临床分册）,1992,12(2):80-82.
-
8陶群,曹雪涛.树突状细胞与移植免疫的研究进展[J].国外医学（免疫学分册）,1998,21(6):314-318.
-
9方福德.基因治疗的伦理问题[J].基础医学与临床,1995,15(5):31-34.
-
10李传明,苏天成.应用脐带血红细胞体外培养恶性疟原虫的研究[J].中国寄生虫学与寄生虫病杂志,1990,8(4):281-283. 被引量：1
