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CD133和CD90在肝细胞癌中的表达及其意义 被引量：4

Expressions and significance of CD133 and CD90 in hepatocellular carcinoma
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摘要 存在于肿瘤组织中的少数具有干细胞性质的细胞群体被称为肿瘤干细胞（CSCs）,可促进肿瘤的发生和发展,也是肿瘤耐药性、复发及转移的根源.有报道CD133和CD90可能为肿瘤干细胞表面标志物,但CD133和CD90在肝癌中的表达及其意义报道尚少.本研究采用免疫组织化学方法检测不同肝组织中CD133及CD90蛋白的表达水平,探讨其在肝癌中的表达情况及其与肝癌生物学特性及预后的关系.
作者 吴晓慧 王顺祥 崔大鹏 李建坤 杨宝明
机构地区 河北医科大学第四医院肝胆外科
出处 《中华肝脏病杂志》 CAS CSCD 北大核心 2011年第5期376-377,共2页 Chinese Journal of Hepatology
基金 河北省普通高等学校强势特色学科肿瘤学建设经费资助项目（冀教高[2005]52号）
关键词 癌 肝细胞 干细胞 CD133 CD90 Carcinoma,hepatocellular Stem cells CD133 CD90
分类号 R735.7 [医药卫生—肿瘤]
  • 相关文献

参考文献7

  • 1Suetsugu A,Nagaki M,Aoki H,et al.Characterization of CD 133+ hepatocellular carcinoma cells as cancer stem/progenitor cells.Biochem Biophys Res Commun,2006,351:820-824.
  • 2Yin S,Li J,Hu C,et al.CD 133 positive hepatocellular carcinoma cells possess high capacity for tumorigenicity.Int J Cancer,2007,120:1444-1450.
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  • 4张华,高志红,刘春玲,文加斌,张阳.原发性肝癌外周血CD133检测的临床意义[J].临床肿瘤学杂志,2009,14(7):606-608. 被引量：3
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二级参考文献7

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共引文献2

同被引文献53

  • 1石永利,吴鸿雁,樊祥山,张明逸,叶庆,冯振卿.上皮-间叶转变相关蛋白在非小细胞肺癌中的表达及其预后意义[J].中国癌症杂志,2011,21(5):342-347. 被引量：12
  • 2陈晋峰,张力建,赵爱莲,王歈,吴楠,熊宏超,梁震,李吉友,黄信孚,杨跃.Thy-1肿瘤标记物在肺癌组织中的异常表达及其对肺癌患者预后的影响[J].中华医学杂志,2005,85(27):1921-1925. 被引量：7
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  • 6SUETSUGU A. NAGAKI M. AOKI H. et al. Characteriza?tion of CD133 + hepatocellular carcinoma cells as cancer stem/ progenitor cells[J]. Biochem Biophys Res Comrnurn , 2006. 351(4) :820-824.
  • 7YIN s, LIJ. HU C. et al. CD133 positive hepatocellular car?cinoma cells possess high capacity for tumorigenicity[J]. IntJ Cancer. 2007.120(7):1444-1450.
  • 8HOJ W. PANG R W. LAU C. et al. Significance of circula?ting endothelial progenitor cells in hepatocellular carcinoma[J]. Hepatology , 2006.44(4) :836-843.
  • 9IMMERVOLL H. HO[M D. SAKARIASSEN P. et al. Ex?pression of the "stem cell marker" CD133 in pancreas and pan?creatic ductal adenocarcinomas[J]. BMC Cancer. 2008.8: 48.
  • 10REGE T A. HAGOODJ S. Thy-l as a regulator of cell-cell and cell-matrix interactions in axon regeneration, apoptcsis , adhesion. migration. cancer. and fibrosis[J]' FASEBJ. 2006.20(8):1045-1054.

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中华肝脏病杂志
2011年 第5期

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