期刊文献+

非酒精性脂肪肝代谢调控与炎症反应的共同通路 被引量:15

The joint pathway of metabolism and inflammation in nonalcoholic fatty liver disease
原文传递
导出
摘要 非酒精性脂肪性肝病(NAFLD)是一种与胰岛素抵抗和遗传易感性密切相关的代谢应激性肝损伤,其病理变化随病程的进展表现有单纯性脂肪肝、脂肪性肝炎(NASH)及其相关的肝硬化和肝细胞癌[12].
出处 《中华肝脏病杂志》 CAS CSCD 北大核心 2011年第5期395-397,共3页 Chinese Journal of Hepatology
基金 上海市优秀学科带头人计划(09XD1403800) 上海市教委重点学科资助项目(J50305,E03008) 国家自然科学基金(30872360)
关键词 脂肪肝 非酒精性 炎症 代谢 Fatty liver,non-alcoholic Inflammation Metabolism
  • 相关文献

参考文献18

  • 1Farrell GC,Larter CZ.Nonalcoholic fatty liver disease:from steatosis to cirrhosis.Hepatology,2006,43(2 Suppl 1):S99-112.
  • 2de Alwis NM,Day CP.Non-alcoholic fatty liver disease:the mist gradually clears.J Hepatol,2008,48 Suppl 1:S104-112.
  • 3Leclerc V,Reichhart JM.The immune response of Drosophila melanogaster.Immunol Rev,2004,198:59-71.
  • 4Song MJ,Kim KH,Yoon JM,et al.Activation of Toll-like receptor 4 is associated with insulin resistance in adipocytes.Biochem Biophys Res Commun,2006,346:739-745.
  • 5Shi H,Kokoeva MV,Inouye K,et al.TLR4 links innate immunity and fatty acid-induced insulin resistance.J Clin Invest,2006,116:3015-3025.
  • 6Caspar-Bauguil S,Cousin B,Galinier A,et al.Adipose tissues as an ancestral immune organ:site-specific change in obesity.FEBS Lett,2005,579:3487-3492.
  • 7Womack J,Tien PC,Feldman J,et al.Obesity and immune cell counts in women.Metabolism,2007,56:998-1004.
  • 8Qin X,Xie X,Fan Y,et al.Peroxisome proliferator-activated recep-tor-delta induces insulin-induced gene-1 and suppresses hepatic li-pogenesis in obese diabetic mice.Hepatology,2008,48:432-441.
  • 9Tajiri K.Shimizu Y,Tsuneyama K,et al.Role of liver-infiltrating CD3+CD56+natural killer T cells in the pathogenesis of nonalcoholic fatty liver disease.Eur J Gastroenterol Hepatol,2009,21:673-680.
  • 10Rensen SS,Slaats Y,Nijhuis J,et al.Increased hepatic myeloperoxidase activity in obese subjects with nonalcoholic steatohepatitis.Am J Pathol,2009,175:1473-1482.

同被引文献134

引证文献15

二级引证文献89

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部