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连环蛋白家族成员P120ctn的作用及相关机制 被引量：3

Catenin Family Member P120ctn
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摘要 连环蛋白P120可在细胞连接处与E-钙黏蛋白结合形成连环蛋白-钙黏蛋白复合体,调控钙黏蛋白介导的细胞黏附作用;在胞质内可与Rho家族GTP酶相互作用调节细胞骨架的运动;在细胞核内可与核转录因子NF-κB和转录抑制因子Kaiso结合,影响炎性反应和细胞增殖.P120对细胞黏附、细胞动力、炎性反应和细胞增殖的影响使其与损伤修复和肿瘤的发生、发展密切相关.深入研究P120的作用及其相关机制对于进一步研究损伤后修复及肿瘤预防和治疗具有深远的意义. P120-catenin （P120ctn） combines E-cadherin to form the complex of catenin-cadherin in cell connection and regulates cell-cell adhesion mediated by cadherin. P120-catenin regulates actin cytoskeleton via Rho family GTPases in the cytoplasm. Moreover, P120-catenin influences inflammatory reaction and cell proliferation through interaction with nuclear transcription factor NF-KB and transcription inhibiting factor Kaiso in the nucleus. Therefore, P120 is closely related with injure restoration and tumor development and progression.
作者 夏传生 王书刚 李丹 李娜萍
机构地区 解放军第 解放军第 华中科技大学同济医学院附属同济医院病理研究所
出处 《医学分子生物学杂志》 CAS CSCD 2011年第2期180-184,共5页 Journal of Medical Molecular Biology
基金 国家自然科学基金（No.81070009）
关键词 连环蛋白P120 细胞黏附 细胞动力 细胞增殖 p120-cateni cell adherence cell dynamics cell proliferation
分类号 R341.3 [医药卫生—基础医学]
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参考文献38

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同被引文献54

  • 1董新军,刘洋,张勇,董千泽,苗原,张俊毅,张迪,王恩华.p120-catenin亚型的表达减弱与肺癌的淋巴结转移明显相关[J].中国肺癌杂志,2008,11(4):529-533. 被引量：3
  • 2陈宇炼,吴冬梅,钱婕,朱中奎,朱奕,王超.吸烟者呼出气中一氧化碳、可吸入颗粒物测定[J].中国公共卫生,2004,20(3):333-333. 被引量：3
  • 3张琼,张昌菊.P120ctn及相关蛋白在宫颈鳞癌中的表达及生物学意义[J].山东医药,2007,47(16):20-21. 被引量：2
  • 4Liu Y,Dong QZ,Zhao Y,et al.P120-catenin isoforms 1Aand3Adifferently affect invasion and proliferation of lung cancercells[J].Exp Cell Res,2009,315(5):890-898.
  • 5Liu Y,Li QC,Miao Y,et al.Ablation of p120-catenin enhancesinvasion and metastasis of human lung cancer cells[J].CancerSci,2009,100(3):441-448.
  • 6Ireton RC,Davis MA,van Hengel J,et al.A novel role for p120cate-nin in E-cadherin function[J].J Cell Biol,2002,159(3):465-476.
  • 7Dai SD,Wang Y,Jiang GY,et al.Kaiso is expressed in lung cancer:its expression and localization is affected by p120ctn[J].Lung cancer(Amsterdam,Netherlands),2010,67(2):205-215.
  • 8Sarrio D,Perez-Mies B,Hardisson D,et al.Cytoplasmic locali-zation of p120ctn and E-cadherin loss characterize lobular breastcarcinoma from preinvasive to metastatic lesions[J].Oncogene,2004,23(19):3272-3283.
  • 9Shibata T,Kokubu A,Sekine S,et al.Cytoplasmic p120ctn reg-ulates the invasive phenotypes of E-cadherin-deficient breastcancer[J].Am J Pathol,2004,164(6):2269-2278.
  • 10Mayerle J,Friess H,Buchler MW,et al.Up-regulation,nuclear im-port,and tumor growth stimulation of the adhesion protein p120inpancreatic cancer[J].Gastroenterology,2003,124(4):949-960.

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医学分子生物学杂志
2011年 第2期

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