骨密度测量的精确度及其重要性

Precision and importance of bone mineral density measurement

骨密度测量用于跟踪骨密度的变化,因此通过精确度研究为骨密度测量的精确度定量,才能反映骨密度的真实变化。通过标准差的均方根(RMS-SD)或百分变异系数的均方根(RMS-%CV)定量骨密度测量的精确度,计算骨密度最小显著性改变(LSC),LSC能够确定进行跟踪测量的最小时间间隔。后前位的腰椎和近端股骨的全股骨区域最适宜作为骨密度的监测位点,它们能够提供骨密度改变幅度和精确度的最佳结合。

Objective Bone mineral density （BMD） measurement is used to follow changes in bone density over time. In order to evaluate the real changes of the bone density,the precision of BMD measurement must be quantified by performing a precision study. The precision, expressed as the root-mean-square standard deviation （RMS-SD） or the root-mean-square percent coefficient of variation （RMS-% CV）, is then used to determine the least significant change （LSC） in bone density. LSC can be used to determine the minimal interval of the follow-up time. Measurements of the PA lumbar spine and the total proximal femur region are the optimum sites for monitoring the changes of bone density. The combination is the best for monitoring the magnitude of BMD change and the precision.