赖氨酰氧化酶与人类疾病

Lysyl Oxidases Related to Human Diseases

赖氨酰氧化酶(lysyl oxidases,LOXs)是一种能够催化细胞外基质蛋白(如胶原和弹性蛋白)交叉连接的酶类,这一功能使其在组织的稳定、重塑和伤口愈合中发挥重要作用.随着研究的不断深入,LOXs在细胞增殖、细胞趋化以及肿瘤发生等过程中也彰显出十分关键的作用.研究发现,一些诸如结缔组织病、剥脱综合症、铜代谢障碍性疾病及盆腔器官脱垂和骨疾等疾病的发生与LOXs有很大关系.综述了LOXs的生物合成、结构特点、多功能性以及与人类疾病的关系.

Lysyl oxidases（LOXs） are a family of anabolic enzymes that function to maintain,heal,and remodel tissue architecture by cross linking the extracellular matrix proteins,collagens and elastins.In a series of studies,LOXs have been considered as a family of multi-functional enzymes,which play an essential role in cell proliferation,cell chemotactical responses and tumor genesis.LOXs have now been implicated in several pathological conditions including connective tissue disease,exfoliation syndrome,disorders of copper metabolism,pelvic organ prolapse and bone disorders,so on.Its biosynthesis,structure characteristics,multi-function and relationship between LOXs and human diseases were summarized.